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Mouse Anti-LILRA4 Recombinant Antibody (CBT2522) (V2LY-0625-LY1498)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2522
Antibody Isotype
IgG1
Application
WB, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human CD85G (AA: extra 24-178) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Leukocyte Immunoglobulin Like Receptor A4
Entrez Gene ID
23547
UniProt ID
P59901
Function
Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354).
Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760).
Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439).
Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354).
Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760).
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Fc-epsilon receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Innate immune responseIEA:UniProtKB-KW
Negative regulation of interferon-alpha productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of toll-like receptor 7 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of toll-like receptor 9 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 24-446
Helical: 447-467
Cytoplasmic: 468-499
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For research use only. Not intended for any clinical use.

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