Mouse Anti-LILRB4 (Extracellular Domain) Recombinant Antibody (293622) (CBMAB-I0133-YY)

Leukocyte Immunoglobulin Like Receptor B4

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).

ILT3; LIR5; CD85K; ILT-3; LIR-5

Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed:11875462).
Receptor for FN1 (PubMed:34089617).
Receptor for apolipoprotein APOE (PubMed:30333625).
Receptor for ALCAM/CD166 (PubMed:29263213).
Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:9151699).
Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed:19833736).
This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed:34089617).
Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed:16493035, PubMed:19833736, PubMed:29263213).
Induces up-regulation of CD86 on dendritic cells (PubMed:19860908).
Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed:11875462).

Adaptive immune responseIEA:UniProtKB-KW
Fc receptor mediated inhibitory signaling pathwayManual Assertion Based On ExperimentIDA:ARUK-UCL
Interleukin-10-mediated signaling pathwayManual Assertion Based On ExperimentIEP:ARUK-UCL
Negative regulation of activated T cell proliferationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of chemokine productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of cytokine production involved in inflammatory responseManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of cytotoxic T cell differentiationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of interferon-gamma productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of interleukin-10 productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of interleukin-2 productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of interleukin-5 productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of interleukin-6 productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of IP-10 productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of MAPK cascadeManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of miRNA transcriptionManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of monocyte activationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of osteoclast differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein localization to nucleusManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of protein tyrosine kinase activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of signaling receptor activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of T cell costimulationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of T cell cytokine productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of T cell proliferationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of T cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of CD8-positive, alpha-beta T cell differentiationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of regulatory T cell differentiationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of T cell anergyManual Assertion Based On ExperimentIMP:ARUK-UCL
Receptor internalizationManual Assertion Based On ExperimentIMP:ARUK-UCL
Tolerance inductionManual Assertion Based On ExperimentIDA:ARUK-UCL

Cell membrane
Ligand binding leads to internalization and translocation to an antigen-processing compartment.

Extracellular: 22-259
Helical: 260-280
Cytoplasmic: 281-448