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LILRB4

LILRB4 (Leukocyte Immunoglobulin Like Receptor B4) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Osteoclast differentiation. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is LILRB3.
Full Name
Leukocyte Immunoglobulin Like Receptor B4
Function
Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed:11875462).
Receptor for FN1 (PubMed:34089617).
Receptor for apolipoprotein APOE (PubMed:30333625).
Receptor for ALCAM/CD166 (PubMed:29263213).
Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:9151699).
Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed:19833736).
This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed:34089617).
Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed:16493035, PubMed:19833736, PubMed:29263213).
Induces up-regulation of CD86 on dendritic cells (PubMed:19860908).
Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed:11875462).
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Fc receptor mediated inhibitory signaling pathwayManual Assertion Based On ExperimentIDA:ARUK-UCL
Interleukin-10-mediated signaling pathwayManual Assertion Based On ExperimentIEP:ARUK-UCL
Negative regulation of activated T cell proliferationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of chemokine productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of cytokine production involved in inflammatory responseManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of cytotoxic T cell differentiationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of interferon-gamma productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of interleukin-10 productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of interleukin-2 productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of interleukin-5 productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of interleukin-6 productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of IP-10 productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of MAPK cascadeManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of miRNA transcriptionManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of monocyte activationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of osteoclast differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein localization to nucleusManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of protein tyrosine kinase activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of signaling receptor activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of T cell costimulationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of T cell cytokine productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of T cell proliferationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of T cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of CD8-positive, alpha-beta T cell differentiationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of regulatory T cell differentiationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of T cell anergyManual Assertion Based On ExperimentIMP:ARUK-UCL
Receptor internalizationManual Assertion Based On ExperimentIMP:ARUK-UCL
Tolerance inductionManual Assertion Based On ExperimentIDA:ARUK-UCL
Cellular Location
Cell membrane
Ligand binding leads to internalization and translocation to an antigen-processing compartment.
Topology
Extracellular: 22-259
Helical: 260-280
Cytoplasmic: 281-448

Anti-LILRB4 antibodies

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Target: LILRB4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJL-1697
Application*: F
Target: LILRB4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-1696
Application*: F
Target: LILRB4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-1695
Application*: E, WB
Target: LILRB4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: ZM4.1
Application*: F
Target: LILRB4
Host: Armenian Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBWJC-4124
Application*: F
Target: LILRB4
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0716
Application*: F
Target: LILRB4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I0760
Application*: E, F, WB
Target: LILRB4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 293623
Application*: WB, F, MC
Target: LILRB4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 293622
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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