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Mouse Anti-LILRB4 Recombinant Antibody (ZM4.1) (CBMAB-C12020-LY)

The product is antibody recognizes LILRB4. The antibody ZM4.1 immunoassay techniques such as: FC.
See all LILRB4 antibodies
Published Data
Fig.1 CSF monocytes express high levels of ILT3.
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Fig.2 Characterization of MS tissue blocks.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
ZM4.1
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin, 0.2% BSA
Preservative
0.09% sodium azide
Concentration
5 μL/Test
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Leukocyte Immunoglobulin Like Receptor B4
Entrez Gene ID
11006
UniProt ID
Q8NHJ6
Function
Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed:11875462).
Receptor for FN1 (PubMed:34089617).
Receptor for apolipoprotein APOE (PubMed:30333625).
Receptor for ALCAM/CD166 (PubMed:29263213).
Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:9151699).
Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed:19833736).
This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed:34089617).
Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed:16493035, PubMed:19833736, PubMed:29263213).
Induces up-regulation of CD86 on dendritic cells (PubMed:19860908).
Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed:11875462).
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Fc receptor mediated inhibitory signaling pathwayManual Assertion Based On ExperimentIDA:ARUK-UCL
Interleukin-10-mediated signaling pathwayManual Assertion Based On ExperimentIEP:ARUK-UCL
Negative regulation of activated T cell proliferationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of chemokine productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of cytokine production involved in inflammatory responseManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of cytotoxic T cell differentiationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of interferon-gamma productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of interleukin-10 productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of interleukin-2 productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of interleukin-5 productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of interleukin-6 productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of IP-10 productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of MAPK cascadeManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of miRNA transcriptionManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of monocyte activationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of osteoclast differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein localization to nucleusManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of protein tyrosine kinase activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of signaling receptor activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of T cell costimulationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of T cell cytokine productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of T cell proliferationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of T cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of CD8-positive, alpha-beta T cell differentiationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of regulatory T cell differentiationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of T cell anergyManual Assertion Based On ExperimentIMP:ARUK-UCL
Receptor internalizationManual Assertion Based On ExperimentIMP:ARUK-UCL
Tolerance inductionManual Assertion Based On ExperimentIDA:ARUK-UCL
Cellular Location
Cell membrane
Ligand binding leads to internalization and translocation to an antigen-processing compartment.
Topology
Extracellular: 22-259
Helical: 260-280
Cytoplasmic: 281-448

Liu, H., Yang, J., Zhang, J., Zhang, P., Zhang, M., Yang, C., ... & Yang, J. (2023). Molecular regulatory mechanism of LILRB4 in the immune response. Central European Journal of Immunology, 48(1).

Yang, T., Qian, Y., Liang, X., Wu, J., Zou, M., & Deng, M. (2022). LILRB4, an immune checkpoint on myeloid cells. Blood Science, 4(02), 49-56.

Singh, L., Muise, E. S., Bhattacharya, A., Grein, J., Javaid, S., Stivers, P., ... & Brandish, P. E. (2021). ILT3 (LILRB4) promotes the immunosuppressive function of tumor-educated human monocytic myeloid-derived suppressor cells. Molecular Cancer Research, 19(4), 702-716.

Sharma, N., Atolagbe, O. T., Ge, Z., & Allison, J. P. (2021). LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy. Journal of Experimental Medicine, 218(7), e20201811.

Churchill, H. R., Fuda, F. S., Xu, J., Deng, M., Zhang, C. C., An, Z., ... & Chen, W. (2021). Leukocyte immunoglobulin‐like receptor B1 and B4 (LILRB1 and LILRB4): Highly sensitive and specific markers of acute myeloid leukemia with monocytic differentiation. Cytometry Part B: Clinical Cytometry, 100(4), 476-487.

Liu, J., Wu, Q., Shi, J., Guo, W., Jiang, X., Zhou, B., & Ren, C. (2020). LILRB4, from the immune system to the disease target. American Journal of Translational Research, 12(7), 3149.

Li, Z., Deng, M., Huang, F., Jin, C., Sun, S., Chen, H., ... & Zhang, C. C. (2020). LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells. Cellular & Molecular Immunology, 17(3), 272-282.

Gui, X., Deng, M., Song, H., Chen, Y., Xie, J., Li, Z., ... & An, Z. (2019). Disrupting LILRB4/APOE interaction by an efficacious humanized antibody reverses T-cell suppression and blocks AML development. Cancer immunology research, 7(8), 1244-1257.

Li, Q., Wei, G., & Tao, T. (2019). Leukocyte immunoglobulin-like receptor B4 (LILRB4) negatively mediates the pathological cardiac hypertrophy by suppressing fibrosis, inflammation and apoptosis via the activation of NF-κB signaling. Biochemical and biophysical research communications, 509(1), 16-23.

Deng, M., Gui, X., Kim, J., Xie, L., Chen, W., Li, Z., ... & Zhang, C. C. (2018). LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration. Nature, 562(7728), 605-609.

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For research use only. Not intended for any clinical use.

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