Mouse Anti-LILRB4 Recombinant Antibody (CBYJL-1697) (CBMAB-L1576-YJ)

Mouse

Human

CBYJL-1697

IgG1, κ

FC

Human CD85k.Immunogen type: Purified protein.

Human

IgG1, κ

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

PBS, pH 7.4

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

LILRB4 a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. LILRB4 belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

ILT3; LIR5; CD85K; ILT-3; LIR-5

Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed:11875462).
Receptor for FN1 (PubMed:34089617).
Receptor for apolipoprotein APOE (PubMed:30333625).
Receptor for ALCAM/CD166 (PubMed:29263213).
Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:9151699).
Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed:19833736).
This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed:34089617).
Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed:16493035, PubMed:19833736, PubMed:29263213).
Induces up-regulation of CD86 on dendritic cells (PubMed:19860908).
Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed:11875462).

Adaptive immune responseIEA:UniProtKB-KW
Fc receptor mediated inhibitory signaling pathwayManual Assertion Based On ExperimentIDA:ARUK-UCL
Interleukin-10-mediated signaling pathwayManual Assertion Based On ExperimentIEP:ARUK-UCL
Negative regulation of activated T cell proliferationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of chemokine productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of cytokine production involved in inflammatory responseManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of cytotoxic T cell differentiationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of interferon-gamma productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of interleukin-10 productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of interleukin-2 productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of interleukin-5 productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of interleukin-6 productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of IP-10 productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of MAPK cascadeManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of miRNA transcriptionManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of monocyte activationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of osteoclast differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein localization to nucleusManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of protein tyrosine kinase activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of signaling receptor activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of T cell costimulationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of T cell cytokine productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of T cell proliferationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of T cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of CD8-positive, alpha-beta T cell differentiationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of regulatory T cell differentiationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of T cell anergyManual Assertion Based On ExperimentIMP:ARUK-UCL
Receptor internalizationManual Assertion Based On ExperimentIMP:ARUK-UCL
Tolerance inductionManual Assertion Based On ExperimentIDA:ARUK-UCL

Cell membrane
Ligand binding leads to internalization and translocation to an antigen-processing compartment.

Extracellular: 22-259
Helical: 260-280
Cytoplasmic: 281-448