Mouse Anti-LIN28B Recombinant Antibody (A910) (CBMAB-AP11491LY)

Name: Mouse Anti-LIN28B Recombinant Antibody (A910)
SKU: CBMAB-AP11491LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A910

Application

IF, IHC, WB

Immunogen

Recombinant protein of human LIN28B

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

LIN28B

Entrez Gene ID

389421

UniProt ID

Q6ZN17

Alternative Names

CSDD2

Function

A11479

Biological Process

miRNA catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of pre-miRNA processingManual Assertion Based On ExperimentIDA:CACAO
Negative regulation of primary miRNA processingManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of miRNA catabolic processManual Assertion Based On ExperimentIMP:CACAO
Pre-miRNA processingManual Assertion Based On ExperimentIMP:UniProtKB
RNA 3'-end processingManual Assertion Based On ExperimentIMP:UniProtKB
RNA destabilizationManual Assertion Based On ExperimentIDA:CACAO

Cellular Location

Nucleus
Nucleus, nucleolus
Cytoplasm
Predominantly nucleolar (PubMed:22118463).
In Huh7 cells, predominantly cytoplasmic, with only a subset of cells exhibiting strong nuclear staining; however, the specificity of the polyclonal antibody used in these experiments has not been not documented (PubMed:16971064).

Qi, M., Xia, Y., Wu, Y., Zhang, Z., Wang, X., Lu, L., ... & Zhan, L. (2022). Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression. Nature communications, 13(1), 897.

Missios, P., da Rocha, E. L., Pearson, D. S., Philipp, J., Aleman, M. M., Pirouz, M., ... & Daley, G. Q. (2021). LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy. The Journal of Clinical Investigation, 131(22).

Yang, Y., Wei, Q., Tang, Y., Wang, Y., Luo, Q., Zhao, H., ... & Yi, P. (2020). Loss of hnRNPA2B1 inhibits malignant capability and promotes apoptosis via down-regulating Lin28B expression in ovarian cancer. Cancer letters, 475, 43-52.

Keskin, T., Bakaric, A., Waszyk, P., Boulay, G., Torsello, M., Cornaz-Buros, S., ... & Stamenkovic, I. (2020). LIN28B underlies the pathogenesis of a subclass of Ewing sarcoma. Cell reports, 30(13), 4567-4583.

Lovnicki, J., Gan, Y., Feng, T., Li, Y., Xie, N., Ho, C. H., ... & Dong, X. (2020). LIN28B promotes the development of neuroendocrine prostate cancer. The Journal of clinical investigation, 130(10), 5338-5348.

Basak, A., Munschauer, M., Lareau, C. A., Montbleau, K. E., Ulirsch, J. C., Hartigan, C. R., ... & Sankaran, V. G. (2020). Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation. Nature genetics, 52(2), 138-145.

Zhang, J., Xu, A., Miao, C., Yang, J., Gu, M., & Song, N. (2019). Prognostic value of Lin28A and Lin28B in various human malignancies: a systematic review and meta-analysis. Cancer cell international, 19(1), 1-8.

Wang, S., Chim, B., Su, Y., Khil, P., Wong, M., Wang, X., ... & Muljo, S. A. (2019). Enhancement of LIN28B-induced hematopoietic reprogramming by IGF2BP3. Genes & development, 33(15-16), 1048-1068.

Guo, W., Hu, Z., Bao, Y., Li, Y., Li, S., Zheng, Q., ... & Huang, S. (2018). A LIN28B tumor-specific transcript in cancer. Cell reports, 22(8), 2016-2025.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-LIN28B Recombinant Antibody (CBYCL-351) (CAT#: CBMAB-L0252-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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