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Rabbit Anti-LLGL1 Recombinant Antibody (D2B5A) (CBMAB-CP1398-LY)

The product is antibody recognizes LLGL1. The antibody D2B5A immunoassay techniques such as: WB,IF (ICC).
See all LLGL1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
D2B5A
Antibody Isotype
IgG
Application
WB, IF (ICC)

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu757 of human LLGL1 protein.
Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
lethal giant larvae homolog 1 (Drosophila)
Entrez Gene ID
Human3996
Monkey707405
UniProt ID
HumanQ15334
MonkeyA0A7N9C858
Function
Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.
Biological Process
AxonogenesisISS:UniProtKB
Cortical actin cytoskeleton organizationManual Assertion Based On ExperimentIDA:UniProtKB
Establishment of spindle orientationManual Assertion Based On ExperimentIBA:GO_Central
Establishment or maintenance of epithelial cell apical/basal polarity1 PublicationIC:ComplexPortal
ExocytosisIEA:UniProtKB-KW
Golgi to plasma membrane transportISS:UniProtKB
Protein-containing complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Regulation of Notch signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Regulation of protein secretionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Early endosome membrane
Golgi apparatus, trans-Golgi network membrane
Golgi apparatus membrane
Cell projection, axon
Cytoplasm, cytoskeleton
Localized to the lateral membrane during the polarization and formation cell-cell contacts. Enriched in developing axons (By similarity).
PTM
Phosphorylated at least at Ser-663 by PRKCI.

Eifert, T., Hsu, C. J., Becker, A. L., Graessle, S., Horne, A., Bemmann, F., ... & Heidel, F. H. (2023). Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia. Leukemia, 37(10), 2027-2035.

Bii, V. M., Rudoy, D., Klezovitch, O., & Vasioukhin, V. (2023). Lethal giant larvae gene family (Llgl1 and Llgl2) functions as a tumor suppressor in mouse skin epidermis. bioRxiv, 2023-03.

Pollitt, E. J., Derrick, C. J., Sánchez-Posada, J., & Noël, E. S. (2023). Llgl1 mediates timely epicardial emergence and establishment of an apical laminin sheath around the trabeculating cardiac ventricle. bioRxiv, 2023-08.

Eifert, T., Schnoeder, T. M., Hsu, C. J., Becker, A. L., Zhang, Q., Mohr, J., ... & Heidel, F. H. (2022). Loss of Cell Fate Determinant LLGL1 Impairs Leukemia Development in Acute Myeloid Leukemia. Blood, 140(Supplement 1), 8680-8681.

Liu, N., Cui, W., Chen, M., Zhang, X., Song, X., & Pan, C. (2021). A 21-bp indel within the LLGL1 gene is significantly associated with litter size in goat. Animal Biotechnology, 32(2), 213-218.

Flinn, M. A., Otten, C., Brandt, Z. J., Bostrom, J. R., Kenarsary, A., Wan, T. C., ... & Link, B. A. (2020). Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes. Development, 147(16), dev193581.

Desuki, A., Staib, F., Gockel, I., Moehler, M., Lang, H., Biesterfeld, S., ... & Schimanski, C. C. (2019). Loss of LLGL1 expression correlates with diffuse gastric cancer and distant peritoneal metastases. Canadian Journal of Gastroenterology and Hepatology, 2019.

Dash, B. P., Schnöder, T. M., Kathner, C., Mohr, J., Weinert, S., Herzog, C., ... & Heidel, F. H. (2018). Diverging impact of cell fate determinants Scrib and Llgl1 on adhesion and migration of hematopoietic stem cells. Journal of Cancer Research and Clinical Oncology, 144, 1933-1944.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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