LLGL1

This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq]

Full Name

lethal giant larvae homolog 1 (Drosophila)

Function

Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.

Biological Process

AxonogenesisISS:UniProtKB
Cortical actin cytoskeleton organizationManual Assertion Based On ExperimentIDA:UniProtKB
Establishment of spindle orientationManual Assertion Based On ExperimentIBA:GO_Central
Establishment or maintenance of epithelial cell apical/basal polarity1 PublicationIC:ComplexPortal
ExocytosisIEA:UniProtKB-KW
Golgi to plasma membrane transportISS:UniProtKB
Protein-containing complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Regulation of Notch signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Regulation of protein secretionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Early endosome membrane
Golgi apparatus, trans-Golgi network membrane
Golgi apparatus membrane
Cell projection, axon
Cytoplasm, cytoskeleton
Localized to the lateral membrane during the polarization and formation cell-cell contacts. Enriched in developing axons (By similarity).

PTM

Phosphorylated at least at Ser-663 by PRKCI.