Mouse Anti-LOXL1 Recombinant Antibody (CBYJL-1907) (CBMAB-L1932-YJ)

Name: Mouse Anti-LOXL1 Recombinant Antibody (CBYJL-1907)
SKU: CBMAB-L1932-YJ
Rating: 5 (1 reviews)

See all LOXL1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJL-1907

Application

ELISA, ICC, IHC, WB

Immunogen

Recombinant LOXL1 (Leu369~Ser574) expressed in E. coli.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

lysyl oxidase like 1

Introduction

LOXL1 is a member of the lysyl oxidase family of proteins. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin. The encoded preproprotein is proteolytically processed to generate the mature enzyme. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Mutations in this gene are associated with exfoliation syndrome.

Entrez Gene ID

4016

UniProt ID

Q08397

Alternative Names

LOL; LOXL; lysyl oxidase homolog 1; lysyl oxidase-like protein 1

Function

Active on elastin and collagen substrates.

Biological Process

Aorta developmentIEA:Ensembl
Collagen fibril organizationManual Assertion Based On ExperimentIBA:GO_Central
Peptidyl-lysine oxidationManual Assertion Based On ExperimentIBA:GO_Central
Protein deaminationManual Assertion Based On ExperimentTAS:UniProtKB
Response to lipopolysaccharideIEA:Ensembl

Cellular Location

Secreted, extracellular space

Involvement in disease

Exfoliation syndrome (XFS):
A disorder characterized by accumulation of abnormal fibrillar deposits in the anterior segment of the eye. In addition to being a cause of glaucoma and glaucomatous optic neuropathy, exfoliation syndrome has also been associated with lens zonule weakness, cataract formation, and systemic vascular complications due to deposition of exfoliation material in extraocular tissues.

PTM

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

Rosell-García, T., Rivas-Muñoz, S., Colige, A., & Rodriguez-Pascual, F. (2022). Cleavage of LOXL1 by BMP1 and ADAMTS14 Proteases Suggests a Role for Proteolytic Processing in the Regulation of LOXL1 Function. International Journal of Molecular Sciences, 23(6), 3285.

Sflomos, G., Battista, L., Aouad, P., De Martino, F., Scabia, V., Stravodimou, A., ... & Brisken, C. (2021). Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1. EMBO Molecular Medicine, 13(3), e13180.

Yang, A., Yan, X., Xu, H., Fan, X., Zhang, M., Huang, T., ... & You, H. (2021). Selective depletion of hepatic stellate cells‐specific LOXL1 alleviates liver fibrosis. The FASEB Journal, 35(10), e21918.

Li, Y., Nie, N., Gong, L., Bao, F., An, C., Cai, H., ... & Zou, X. (2021). Structural, functional and molecular pathogenesis of pelvic organ prolapse in patient and Loxl1 deficient mice. Aging (Albany NY), 13(24), 25886.

Yu, H., Ding, J., Zhu, H., Jing, Y., Zhou, H., Tian, H., ... & Wang, X. (2020). LOXL1 confers antiapoptosis and promotes gliomagenesis through stabilizing BAG2. Cell Death & Differentiation, 27(11), 3021-3036.

Hu, L., Wang, J., Wang, Y., Wu, L., Wu, C., Mao, B., ... & Chin, Y. E. (2020). LOXL1 modulates the malignant progression of colorectal cancer by inhibiting the transcriptional activity of YAP. Cell Communication and Signaling, 18, 1-16.

Zeltz, C., Pasko, E., Cox, T. R., Navab, R., & Tsao, M. S. (2019). LOXL1 is regulated by integrin α11 and promotes non-small cell lung cancer tumorigenicity. Cancers, 11(5), 705.

Sun, Q., Li, J., Li, F., Li, H., Bei, S., Zhang, X., & Feng, L. (2019). LncRNA LOXL1‐AS1 facilitates the tumorigenesis and stemness of gastric carcinoma via regulation of miR‐708‐5p/USF1 pathway. Cell proliferation, 52(6), e12687.

Chen, S., Li, W., & Guo, A. (2019). LOXL1-AS1 predicts poor prognosis and promotes cell proliferation, migration, and invasion in osteosarcoma. Bioscience Reports, 39(4), BSR20190447.

Bernstein, A. M., Ritch, R., & Wolosin, J. M. (2019). LOXL1 folding in exfoliation glaucoma. Advances in protein chemistry and structural biology, 118, 273-288.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-LOXL1 Recombinant Antibody (CBYJL-1907)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-LOXL1 Recombinant Antibody (CBYCL-429) (CAT#: CBMAB-L0330-YC)

Mouse Anti-LOXL1 Recombinant Antibody (CBYJL-1908) (CAT#: CBMAB-L1933-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry