LOXL1

This gene encodes a member of the lysyl oxidase family of proteins. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Active on elastin and collagen substrates.
Full Name
lysyl oxidase like 1
Function
Active on elastin and collagen substrates.
Biological Process
Aorta developmentIEA:Ensembl
Collagen fibril organizationManual Assertion Based On ExperimentIBA:GO_Central
Peptidyl-lysine oxidationManual Assertion Based On ExperimentIBA:GO_Central
Protein deaminationManual Assertion Based On ExperimentTAS:UniProtKB
Response to lipopolysaccharideIEA:Ensembl
Cellular Location
Secreted, extracellular space
Involvement in disease
Exfoliation syndrome (XFS):
A disorder characterized by accumulation of abnormal fibrillar deposits in the anterior segment of the eye. In addition to being a cause of glaucoma and glaucomatous optic neuropathy, exfoliation syndrome has also been associated with lens zonule weakness, cataract formation, and systemic vascular complications due to deposition of exfoliation material in extraocular tissues.
PTM
The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
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Anti-LOXL1 antibodies

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Mouse Anti-LOXL1 Recombinant Antibody (CBYJL-1907) (CBMAB-L1932-YJ)

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Target: LOXL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1907
Application*: E, IC, IH, WB
Datasheet SDS

Mouse Anti-LOXL1 Recombinant Antibody (CBYCL-429) (CBMAB-L0330-YC)

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Target: LOXL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCL-429
Application*: E, WB
Datasheet SDS

Mouse Anti-LOXL1 Recombinant Antibody (CBYJL-1908) (CBMAB-L1933-YJ)

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Target: LOXL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1908
Application*: IC, P, E, WB
Datasheet SDS

Human Recombinant LOXL1 protein, GST Tag (V2LY-0526-LY5334)

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Target: LOXL1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 292-end
Tag: GST Tag
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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