Human Recombinant LOXL1 protein, GST Tag (V2LY-0526-LY5334)

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Basic Information

Expressed Host
Baculovirus-Insect Cells
Protein Species
Human
Tag
GST Tag
Protein Construction
This product is Human Recombinant LOXL1 protein, GST Tag consist of Amino Acid: 292-end and predicts a molecular mass of 61 kDa.
Molecule Mass
61 kDa
Sequence
Amino Acid: 292-end
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
Batch dependent.
Endotoxin
Please contact us for more information.
Format
Liquid
Buffer
Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol
Preservative
None
Storage
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
More Infomation

Target

Full Name
lysyl oxidase like 1
Function
Active on elastin and collagen substrates.
Biological Process
Aorta developmentIEA:Ensembl
Collagen fibril organizationManual Assertion Based On ExperimentIBA:GO_Central
Peptidyl-lysine oxidationManual Assertion Based On ExperimentIBA:GO_Central
Protein deaminationManual Assertion Based On ExperimentTAS:UniProtKB
Response to lipopolysaccharideIEA:Ensembl
Cellular Location
Secreted, extracellular space
Involvement in disease
Exfoliation syndrome (XFS):
A disorder characterized by accumulation of abnormal fibrillar deposits in the anterior segment of the eye. In addition to being a cause of glaucoma and glaucomatous optic neuropathy, exfoliation syndrome has also been associated with lens zonule weakness, cataract formation, and systemic vascular complications due to deposition of exfoliation material in extraocular tissues.
PTM
The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

Rosell-García, T., Rivas-Muñoz, S., Colige, A., & Rodriguez-Pascual, F. (2022). Cleavage of LOXL1 by BMP1 and ADAMTS14 Proteases Suggests a Role for Proteolytic Processing in the Regulation of LOXL1 Function. International Journal of Molecular Sciences, 23(6), 3285.

Sflomos, G., Battista, L., Aouad, P., De Martino, F., Scabia, V., Stravodimou, A., ... & Brisken, C. (2021). Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1. EMBO Molecular Medicine, 13(3), e13180.

Yang, A., Yan, X., Xu, H., Fan, X., Zhang, M., Huang, T., ... & You, H. (2021). Selective depletion of hepatic stellate cells‐specific LOXL1 alleviates liver fibrosis. The FASEB Journal, 35(10), e21918.

Li, Y., Nie, N., Gong, L., Bao, F., An, C., Cai, H., ... & Zou, X. (2021). Structural, functional and molecular pathogenesis of pelvic organ prolapse in patient and Loxl1 deficient mice. Aging (Albany NY), 13(24), 25886.

Yu, H., Ding, J., Zhu, H., Jing, Y., Zhou, H., Tian, H., ... & Wang, X. (2020). LOXL1 confers antiapoptosis and promotes gliomagenesis through stabilizing BAG2. Cell Death & Differentiation, 27(11), 3021-3036.

Hu, L., Wang, J., Wang, Y., Wu, L., Wu, C., Mao, B., ... & Chin, Y. E. (2020). LOXL1 modulates the malignant progression of colorectal cancer by inhibiting the transcriptional activity of YAP. Cell Communication and Signaling, 18, 1-16.

Zeltz, C., Pasko, E., Cox, T. R., Navab, R., & Tsao, M. S. (2019). LOXL1 is regulated by integrin α11 and promotes non-small cell lung cancer tumorigenicity. Cancers, 11(5), 705.

Sun, Q., Li, J., Li, F., Li, H., Bei, S., Zhang, X., & Feng, L. (2019). LncRNA LOXL1‐AS1 facilitates the tumorigenesis and stemness of gastric carcinoma via regulation of miR‐708‐5p/USF1 pathway. Cell proliferation, 52(6), e12687.

Chen, S., Li, W., & Guo, A. (2019). LOXL1-AS1 predicts poor prognosis and promotes cell proliferation, migration, and invasion in osteosarcoma. Bioscience Reports, 39(4), BSR20190447.

Bernstein, A. M., Ritch, R., & Wolosin, J. M. (2019). LOXL1 folding in exfoliation glaucoma. Advances in protein chemistry and structural biology, 118, 273-288.

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For research use only. Not intended for any clinical use.

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