Mouse Anti-LPA Recombinant Antibody (4H1) (CBMAB-L1945-YJ)

Name: Mouse Anti-LPA Recombinant Antibody (4H1)
SKU: CBMAB-L1945-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4H1

Application

ELISA, ICC, IF, IHC-P, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Preservative

0.05% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

S. aureus MAGI2

Introduction

LPA is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. LPA constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, LPA contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence.

Entrez Gene ID

4018

UniProt ID

P08519

Alternative Names

LP; AK38; APOA

Function

Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.

Biological Process

Blood circulationManual Assertion Based On ExperimentTAS:ProtInc
Lipid metabolic process1 PublicationNAS:ProtInc
Lipid transportIEA:UniProtKB-KW
ProteolysisManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Extracellular region
Extracellular space
Extrinsic component of plasma membrane
Plasma lipoprotein particle

PTM

N- and O-glycosylated. The N-glycans are complex biantennary structures present in either a mono- or disialylated state. The O-glycans are mostly (80%) represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated and non-sialylated O-glycans also detected.

Lau, F. D., & Giugliano, R. P. (2022). Lipoprotein (a) and its significance in cardiovascular disease: a review. Jama Cardiology.

Coassin, S., & Kronenberg, F. (2022). Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene. Atherosclerosis, 349, 17-35.

Gu, J. X., Huang, J., Li, S. S., Zhou, L. H., Yang, M., Li, Y., ... & Su, M. (2022). Elevated lipoprotein (a) and genetic polymorphisms in the LPA gene may predict cardiovascular events. Scientific Reports, 12(1), 3588.

Kamstrup, P. R. (2021). Lipoprotein (a) and cardiovascular disease. Clinical chemistry, 67(1), 154-166.

Trinder, M., Uddin, M. M., Finneran, P., Aragam, K. G., & Natarajan, P. (2021). Clinical utility of lipoprotein (a) and LPA genetic risk score in risk prediction of incident atherosclerotic cardiovascular disease. JAMA cardiology, 6(3), 287-295.

Ruscica, M., Sirtori, C. R., Corsini, A., Watts, G. F., & Sahebkar, A. (2021). Lipoprotein (a): Knowns, unknowns and uncertainties. Pharmacological research, 173, 105812.

Miksenas, H., Januzzi, J. L., & Natarajan, P. (2021). Lipoprotein (a) and cardiovascular diseases. JAMA, 326(4), 352-353.

Schachtl-Riess, J. F., Kheirkhah, A., Grüneis, R., Di Maio, S., Schoenherr, S., Streiter, G., ... & Coassin, S. (2021). Frequent LPA KIV-2 variants lower lipoprotein (a) concentrations and protect against coronary artery disease. Journal of the American College of Cardiology, 78(5), 437-449.

Langsted, A., Kamstrup, P. R., & Nordestgaard, B. G. (2019). High lipoprotein (a) and high risk of mortality. European heart journal, 40(33), 2760-2770.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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