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Mouse Anti-LPA Recombinant Antibody (CBT4733) (V2LY-0625-LY2748)


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Tested Data
Mouse Anti-LPA Recombinant Antibody (CBT4733) (V2LY-0625-LY2748) in WB
Mouse Anti-LPA Recombinant Antibody (CBT4733) (V2LY-0625-LY2748) in WB
Mouse Anti-LPA Recombinant Antibody (CBT4733) (V2LY-0625-LY2748) in IHC
Mouse Anti-LPA Recombinant Antibody (CBT4733) (V2LY-0625-LY2748) in IHC
Mouse Anti-LPA Recombinant Antibody (CBT4733) (V2LY-0625-LY2748) in IHC
Mouse Anti-LPA Recombinant Antibody (CBT4733) (V2LY-0625-LY2748) in IHC
Mouse Anti-LPA Recombinant Antibody (CBT4733) (V2LY-0625-LY2748) in IHC
Mouse Anti-LPA Recombinant Antibody (CBT4733) (V2LY-0625-LY2748) in IHC
Mouse Anti-LPA Recombinant Antibody (CBT4733) (V2LY-0625-LY2748) in IF
Mouse Anti-LPA Recombinant Antibody (CBT4733) (V2LY-0625-LY2748) in IF
Mouse Anti-LPA Recombinant Antibody (CBT4733) (V2LY-0625-LY2748) in ELISA
Mouse Anti-LPA Recombinant Antibody (CBT4733) (V2LY-0625-LY2748) in ELISA

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4733
Antibody Isotype
IgG1
Application
IHC, ICC

Basic Information

Immunogen
Purified recombinant fragment of human LPA (AA:1823-2013) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
4018
UniProt ID
P08519
Function
Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.
Biological Process
Blood circulationManual Assertion Based On ExperimentTAS:ProtInc
Lipid metabolic process1 PublicationNAS:ProtInc
Lipid transportIEA:UniProtKB-KW
ProteolysisManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Extracellular region
Extracellular space
Extrinsic component of plasma membrane
Plasma lipoprotein particle
PTM
N- and O-glycosylated. The N-glycans are complex biantennary structures present in either a mono- or disialylated state. The O-glycans are mostly (80%) represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated and non-sialylated O-glycans also detected.
More Infomation

Lau, F. D., & Giugliano, R. P. (2022). Lipoprotein (a) and its significance in cardiovascular disease: a review. Jama Cardiology.

Coassin, S., & Kronenberg, F. (2022). Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene. Atherosclerosis, 349, 17-35.

Gu, J. X., Huang, J., Li, S. S., Zhou, L. H., Yang, M., Li, Y., ... & Su, M. (2022). Elevated lipoprotein (a) and genetic polymorphisms in the LPA gene may predict cardiovascular events. Scientific Reports, 12(1), 3588.

Kamstrup, P. R. (2021). Lipoprotein (a) and cardiovascular disease. Clinical chemistry, 67(1), 154-166.

Trinder, M., Uddin, M. M., Finneran, P., Aragam, K. G., & Natarajan, P. (2021). Clinical utility of lipoprotein (a) and LPA genetic risk score in risk prediction of incident atherosclerotic cardiovascular disease. JAMA cardiology, 6(3), 287-295.

Ruscica, M., Sirtori, C. R., Corsini, A., Watts, G. F., & Sahebkar, A. (2021). Lipoprotein (a): Knowns, unknowns and uncertainties. Pharmacological research, 173, 105812.

Miksenas, H., Januzzi, J. L., & Natarajan, P. (2021). Lipoprotein (a) and cardiovascular diseases. JAMA, 326(4), 352-353.

Schachtl-Riess, J. F., Kheirkhah, A., Grüneis, R., Di Maio, S., Schoenherr, S., Streiter, G., ... & Coassin, S. (2021). Frequent LPA KIV-2 variants lower lipoprotein (a) concentrations and protect against coronary artery disease. Journal of the American College of Cardiology, 78(5), 437-449.

Langsted, A., Kamstrup, P. R., & Nordestgaard, B. G. (2019). High lipoprotein (a) and high risk of mortality. European heart journal, 40(33), 2760-2770.

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For research use only. Not intended for any clinical use.

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