LPA
The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I.
Full Name
S. aureus MAGI2
Function
Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.
Biological Process
Blood circulationManual Assertion Based On ExperimentTAS:ProtInc
Lipid metabolic process1 PublicationNAS:ProtInc
Lipid transportIEA:UniProtKB-KW
ProteolysisManual Assertion Based On ExperimentIBA:GO_Central
Lipid metabolic process1 PublicationNAS:ProtInc
Lipid transportIEA:UniProtKB-KW
ProteolysisManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Extracellular region
Extracellular space
Extrinsic component of plasma membrane
Plasma lipoprotein particle
Extracellular space
Extrinsic component of plasma membrane
Plasma lipoprotein particle
PTM
N- and O-glycosylated. The N-glycans are complex biantennary structures present in either a mono- or disialylated state. The O-glycans are mostly (80%) represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated and non-sialylated O-glycans also detected.
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Anti-LPA antibodies
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Target: LPA
Host: Goat
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYR0677
Target: LPA
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human
Clone: CBFYM-1221
Application*: E, WB
Target: LPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-434
Application*: E, P, WB
Target: LPA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCL-433
Application*: WB, IC, P, C, E
Target: LPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4H1
Application*: E, IC, IF, P, WB
Target: LPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1914
Application*: E, IC, IH, WB
Target: LPA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT164
Application*: WB, P, IF, E
Target: LPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4733
Application*: IH, IC
Target: LPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4510
Application*: IH
Target: LPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8F6A9, 8H5C5
Application*: ELISA, WB, IHC
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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