Mouse Anti-LPO Recombinant Antibody (CBXS-3730) (CBMAB-S1005-CQ)

Name: Mouse Anti-LPO Recombinant Antibody (CBXS-3730)
SKU: CBMAB-S1005-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-3730

Application

WB, ICC, IHC-P, IHC-Fr, ELISA, IP, IF, FC

Immunogen

Lactoperoxidase

Specificity

Rat

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 50% glycerol

Preservative

0.02% sodium azide

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

LPO

Introduction

This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.

Entrez Gene ID

287610

UniProt ID

D4A400

Alternative Names

SPO

Function

Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (By similarity).
May contribute to airway host defense against infection.

Biological Process

Defense response to bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Detection of chemical stimulus involved in sensory perception of bitter tasteManual Assertion Based On ExperimentIDA:UniProtKB
Hydrogen peroxide catabolic processIEA:UniProtKB-KW
Response to oxidative stress1 PublicationNAS:UniProtKB

Cellular Location

Secreted

Yamakaze, J., & Lu, Z. (2021). Deletion of the lactoperoxidase gene causes multisystem inflammation and tumors in mice. Scientific Reports, 11(1), 12429.

Welk, A., Patjek, S., Gärtner, M., Baguhl, R., Schwahn, C., & Below, H. (2021). Antibacterial and antiplaque efficacy of a lactoperoxidase-thiocyanate-hydrogen-peroxide-system-containing lozenge. BMC microbiology, 21, 1-12.

Viswanathan, V., Rani, C., Ahmad, N., Singh, P. K., Sharma, P., Kaur, P., ... & Singh, T. P. (2021). Structure of yak lactoperoxidase at 1.55 Å resolution. The Protein Journal, 40, 8-18.

Buys, E. M., & Seifu, E. (2021). Enzymes indigenous to milk: Lactoperoxidase. Elsevier.

El-Fakharany, E. M. (2021). Nanoformulation approach for improved stability and efficiency of lactoperoxidase. Preparative Biochemistry & Biotechnology, 51(7), 629-641.

Al-Shehri, S. S., Duley, J. A., & Bansal, N. (2020). Xanthine oxidase-lactoperoxidase system and innate immunity: Biochemical actions and physiological roles. Redox biology, 34, 101524.

Kalin, R., Koksal, Z., Kalin, P., Karaman, M., Gulcin, İ., & Ozdemir, H. (2020). In vitro effects of standard antioxidants on lactoperoxidase enzyme–A molecular docking approach. Journal of Biochemical and Molecular Toxicology, 34(1), e22421.

Köksal, Z., & Alim, Z. (2020). Lactoperoxidase, an antimicrobial enzyme, is inhibited by some indazoles. Drug and chemical toxicology, 43(1), 22-26.

Magacz, M., Kędziora, K., Sapa, J., & Krzyściak, W. (2019). The significance of lactoperoxidase system in oral health: Application and efficacy in oral hygiene products. International journal of molecular sciences, 20(6), 1443.

Al-Baarri, A. N. M., Damayanti, N. T., Legowo, A. M., Tekiner, İ. H., & Hayakawa, S. (2019). Enhanced antibacterial activity of lactoperoxidase–thiocyanate–hydrogen peroxide system in reduced-lactose milk whey. International Journal of Food Science, 2019.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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