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Mouse Anti-LPO Recombinant Antibody (CBXS-3730) (CBMAB-S1005-CQ)

This product is a mouse antibody that recognizes LPO. The antibody CBXS-3730 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA, IP, IF, FC.
See all LPO antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBXS-3730
Antibody Isotype
IgG2b, κ
Application
WB, ICC, IHC-P, IHC-Fr, ELISA, IP, IF, FC

Basic Information

Immunogen
Lactoperoxidase
Specificity
Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LPO
Introduction
This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
Entrez Gene ID
287610
UniProt ID
D4A400
Alternative Names
SPO
Function
Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (By similarity).
May contribute to airway host defense against infection.
Biological Process
Defense response to bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Detection of chemical stimulus involved in sensory perception of bitter tasteManual Assertion Based On ExperimentIDA:UniProtKB
Hydrogen peroxide catabolic processIEA:UniProtKB-KW
Response to oxidative stress1 PublicationNAS:UniProtKB
Cellular Location
Secreted

Yamakaze, J., & Lu, Z. (2021). Deletion of the lactoperoxidase gene causes multisystem inflammation and tumors in mice. Scientific Reports, 11(1), 12429.

Welk, A., Patjek, S., Gärtner, M., Baguhl, R., Schwahn, C., & Below, H. (2021). Antibacterial and antiplaque efficacy of a lactoperoxidase-thiocyanate-hydrogen-peroxide-system-containing lozenge. BMC microbiology, 21, 1-12.

Viswanathan, V., Rani, C., Ahmad, N., Singh, P. K., Sharma, P., Kaur, P., ... & Singh, T. P. (2021). Structure of yak lactoperoxidase at 1.55 Å resolution. The Protein Journal, 40, 8-18.

Buys, E. M., & Seifu, E. (2021). Enzymes indigenous to milk: Lactoperoxidase. Elsevier.

El-Fakharany, E. M. (2021). Nanoformulation approach for improved stability and efficiency of lactoperoxidase. Preparative Biochemistry & Biotechnology, 51(7), 629-641.

Al-Shehri, S. S., Duley, J. A., & Bansal, N. (2020). Xanthine oxidase-lactoperoxidase system and innate immunity: Biochemical actions and physiological roles. Redox biology, 34, 101524.

Kalin, R., Koksal, Z., Kalin, P., Karaman, M., Gulcin, İ., & Ozdemir, H. (2020). In vitro effects of standard antioxidants on lactoperoxidase enzyme–A molecular docking approach. Journal of Biochemical and Molecular Toxicology, 34(1), e22421.

Köksal, Z., & Alim, Z. (2020). Lactoperoxidase, an antimicrobial enzyme, is inhibited by some indazoles. Drug and chemical toxicology, 43(1), 22-26.

Magacz, M., Kędziora, K., Sapa, J., & Krzyściak, W. (2019). The significance of lactoperoxidase system in oral health: Application and efficacy in oral hygiene products. International journal of molecular sciences, 20(6), 1443.

Al-Baarri, A. N. M., Damayanti, N. T., Legowo, A. M., Tekiner, İ. H., & Hayakawa, S. (2019). Enhanced antibacterial activity of lactoperoxidase–thiocyanate–hydrogen peroxide system in reduced-lactose milk whey. International Journal of Food Science, 2019.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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