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Mouse Anti-LRAT Recombinant Antibody (A923) (CBMAB-AP4311LY)

The product is antibody recognizes LRAT. The antibody A923 immunoassay techniques such as: ELISA, IF, IHC, WB.
See all LRAT antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A923
Antibody Isotype
IgG1
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
Peptide Sequence - RDQRSVLASA (amino acids 190 -199)
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
Entrez Gene ID
9227
UniProt ID
O95237
Function
Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters (PubMed:9920938).
Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (By similarity).
Biological Process
Cellular response to leukemia inhibitory factorIEA:Ensembl
Positive regulation of lipid transportIEA:Ensembl
Response to bacteriumIEA:Ensembl
Response to retinoic acidIEA:Ensembl
Response to vitamin AIEA:Ensembl
Retinoid metabolic processTAS:Reactome
Retinol metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Visual perceptionIEA:UniProtKB-KW
Vitamin A metabolic processISS:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Rough endoplasmic reticulum
Endosome, multivesicular body
Cytoplasm, perinuclear region
Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells (By similarity).
Involvement in disease
Leber congenital amaurosis 14 (LCA14):
A severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus.
Topology
Cytoplasmic: 1-194
Helical: 195-215
Lumenal: 216-230
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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