Mouse Anti-LRP3 Recombinant Antibody (CBT2086) (V2LY-0625-LY1040)

Name: Mouse Anti-LRP3 Recombinant Antibody (CBT2086)
SKU: V2LY-0625-LY1040
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBT2086

Antibody Isotype

IgG1

Application

WB, ICC, FC

Basic Information

Immunogen

Purified recombinant fragment of human LRP3 (AA: extra 43-184) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
ICC	1:100-1:500
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

LDL receptor related protein 3

Entrez Gene ID

4037

UniProt ID

O75074

Function

Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.

Biological Process

Negative regulation of fat cell differentiationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of osteoblast differentiationManual Assertion Based On ExperimentIMP:ARUK-UCL
Receptor-mediated endocytosisManual Assertion Based On ExperimentTAS:ProtInc
Transport across blood-brain barrier1 PublicationNAS:ARUK-UCL

Cellular Location

Membrane
Membrane, coated pit

Topology

Extracellular: 37-496
Helical: 497-517
Cytoplasmic: 518-770

More Infomation

References

Shi, Y., Cao, C., Yang, F., Shao, J., Hu, X., Cheng, J., ... & Ao, Y. (2022). Inhibition of LDL receptor-related protein 3 suppresses chondrogenesis of stem cells, inhibits proliferation, and promotes apoptosis. Biochemical and Biophysical Research Communications, 635, 77-83.

Cuchillo-Ibañez, I., Lennol, M. P., Escamilla, S., Mata-Balaguer, T., Valverde-Vozmediano, L., Lopez-Font, I., ... & Sáez-Valero, J. (2021). The apolipoprotein receptor LRP3 compromises APP levels. Alzheimer's Research & Therapy, 13, 1-17.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-LRP3 Recombinant Antibody (CBYJL-1971)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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