Mouse Anti-LRP3 Recombinant Antibody (CBYJL-1971) (CBMAB-L2054-YJ)

Name: Mouse Anti-LRP3 Recombinant Antibody (CBYJL-1971)
SKU: CBMAB-L2054-YJ
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYJL-1971

Antibody Isotype

IgG2a, κ

Application

ELISA, WB

Basic Information

Immunogen

Partial recombinant corresponding to aa 671-770 from human LRP3 (NP_002324) with GST tag. MW of the GST tag alone is 26kD.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 671-770

Target

Full Name

LDL receptor related protein 3

Introduction

An important paralog of this gene is LRP12.

Entrez Gene ID

4037

UniProt ID

O75074

Alternative Names

low-density lipoprotein receptor-related protein 3; 105 kDa low-density lipoprotein receptor-related protein; CTD-2540B15.13; LRP-3; hLRp105

Function

Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.

Biological Process

Negative regulation of fat cell differentiationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of osteoblast differentiationManual Assertion Based On ExperimentIMP:ARUK-UCL
Receptor-mediated endocytosisManual Assertion Based On ExperimentTAS:ProtInc
Transport across blood-brain barrier1 PublicationNAS:ARUK-UCL

Cellular Location

Membrane
Membrane, coated pit

Topology

Extracellular: 37-496
Helical: 497-517
Cytoplasmic: 518-770

More Infomation

References

Shi, Y., Cao, C., Yang, F., Shao, J., Hu, X., Cheng, J., ... & Ao, Y. (2022). Inhibition of LDL receptor-related protein 3 suppresses chondrogenesis of stem cells, inhibits proliferation, and promotes apoptosis. Biochemical and Biophysical Research Communications, 635, 77-83.

Cuchillo-Ibañez, I., Lennol, M. P., Escamilla, S., Mata-Balaguer, T., Valverde-Vozmediano, L., Lopez-Font, I., ... & Sáez-Valero, J. (2021). The apolipoprotein receptor LRP3 compromises APP levels. Alzheimer's Research & Therapy, 13, 1-17.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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