LRP3
An important paralog of this gene is LRP12.
Full Name
LDL receptor related protein 3
Function
Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.
Biological Process
Negative regulation of fat cell differentiationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of osteoblast differentiationManual Assertion Based On ExperimentIMP:ARUK-UCL
Receptor-mediated endocytosisManual Assertion Based On ExperimentTAS:ProtInc
Transport across blood-brain barrier1 PublicationNAS:ARUK-UCL
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of osteoblast differentiationManual Assertion Based On ExperimentIMP:ARUK-UCL
Receptor-mediated endocytosisManual Assertion Based On ExperimentTAS:ProtInc
Transport across blood-brain barrier1 PublicationNAS:ARUK-UCL
Cellular Location
Membrane
Membrane, coated pit
Membrane, coated pit
Topology
Extracellular: 37-496
Helical: 497-517
Cytoplasmic: 518-770
Helical: 497-517
Cytoplasmic: 518-770
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Anti-LRP3 antibodies
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Target: LRP3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-1971
Application*: E, WB
Target: LRP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2086
Application*: WB, IC, F
More Infomation
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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