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Mouse Anti-LRRC25 Recombinant Antibody (CBYJL-2002) (CBMAB-L2096-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Leucine Rich Repeat Containing 25 (LRRC25). The antibody can be used for immunoassay techniques, such as WB, IHC, FC.
See all LRRC25 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-2002
Antibody Isotype
IgG1
Application
WB, IHC, FC

Basic Information

Immunogen
Full length human recombinant protein of human LRRC25(NP_660299) produced in HEK293T cell.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Leucine Rich Repeat Containing 25
Introduction
Diseases associated with LRRC25 include Transient Global Amnesia.
Entrez Gene ID
126364
UniProt ID
Q8N386
Alternative Names
MAPA; leucine-rich repeat-containing protein 25; monocyte and plasmacytoid activated molecule; monocyte and plasmacytoid-activated protein
Function
Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy (PubMed:29288164).
Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.
Biological Process
Membrane
Cytoplasm
Topology
Extracellular: 21-165
Helical: 166-186
Cytoplasmic: 187-305
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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