Mouse Anti-LRRC25 Recombinant Antibody (CBYJL-2006) (CBMAB-L2102-YJ)

Name: Mouse Anti-LRRC25 Recombinant Antibody (CBYJL-2006)
SKU: CBMAB-L2102-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJL-2006

Application

FC, IHC-P, WB

Immunogen

Full length human recombinant protein of human LRRC25(NP_660299) produced in HEK293T cell.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Leucine Rich Repeat Containing 25

Introduction

Diseases associated with LRRC25 include Transient Global Amnesia.

Entrez Gene ID

126364

UniProt ID

Q8N386

Alternative Names

MAPA; leucine-rich repeat-containing protein 25; monocyte and plasmacytoid activated molecule; monocyte and plasmacytoid-activated protein

Function

Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy (PubMed:29288164).
Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.

Biological Process

Membrane
Cytoplasm

Topology

Extracellular: 21-165
Helical: 166-186
Cytoplasmic: 187-305

Sheng, G., Chu, H., Duan, H., Wang, W., Tian, N., Liu, D., ... & Sun, Z. (2023). LRRC25 Inhibits IFN-γ Secretion by Microglia to Negatively Regulate Anti-Tuberculosis Immunity in Mice. Microorganisms, 11(10), 2500.

Yang, W., Li, D., Ru, Y., Bai, J., Ren, J., Zhang, J., ... & Zheng, H. (2020). Foot-and-mouth disease virus 3A protein causes upregulation of autophagy-related protein LRRC25 to inhibit the G3BP1-mediated RIG-like helicase-signaling pathway. Journal of virology, 94(8), 10-1128.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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