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Mouse Anti-LRRFIP2 Recombinant Antibody (377C3a) (CBMAB-L2150-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lrr Binding Flii Interacting Protein 2 (LRRFIP2). The antibody can be used for immunoassay techniques, such as Dot, ICC.
See all LRRFIP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
377C3a
Antibody Isotype
IgG2a
Application
Dot, ICC

Basic Information

Immunogen
LRRFIP2 antibody was raised in mouse using recombinant Human Leucine Rich Repeat (In Flii) Interacting Protein 2.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
leucine rich repeat (in FLII) interacting protein 2
Introduction
LRRFIP2, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which causes activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, LRRFIP2 can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex.
Entrez Gene ID
9209
UniProt ID
Q9Y608
Alternative Names
HUFI-2; leucine-rich repeat flightless-interacting protein 2; LRR FLII-interacting protein 2; leucine rich repeat (in FLII) interacting protein 2
Function
May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Biological Process
Regulation of transcription, DNA-templatedIEA:InterPro
Wnt signaling pathwayIEA:UniProtKB-KW
PTM
Ser-190 and Ser-202 are phosphorylated in response to LPS stimulation. Ser-202 phosphorylation regulates the LPS-induced interaction with MYD88.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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