LRRFIP2

LRRFIP2, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which causes activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, LRRFIP2 can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex.

leucine rich repeat (in FLII) interacting protein 2

May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.

Regulation of transcription, DNA-templatedIEA:InterPro
Wnt signaling pathwayIEA:UniProtKB-KW

Ser-190 and Ser-202 are phosphorylated in response to LPS stimulation. Ser-202 phosphorylation regulates the LPS-induced interaction with MYD88.