Mouse Anti-LRRFIP2 Recombinant Antibody (CBYCL-487) (CBMAB-L0388-YC)

Name: Mouse Anti-LRRFIP2 Recombinant Antibody (CBYCL-487)
SKU: CBMAB-L0388-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYCL-487

Application

Immunogen

Synthetic peptide corresponding to the N-terminal region of human LRRFIP2

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

N-terminus

More Infomation

Target

Full Name

leucine rich repeat (in FLII) interacting protein 2

Introduction

x, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex.

Entrez Gene ID

9209

UniProt ID

Q9Y608

Alternative Names

HUFI-2

Function

May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.

Biological Process

Regulation of transcription, DNA-templatedIEA:InterPro
Wnt signaling pathwayIEA:UniProtKB-KW

PTM

Ser-190 and Ser-202 are phosphorylated in response to LPS stimulation. Ser-202 phosphorylation regulates the LPS-induced interaction with MYD88.

Lee, J., Pang, K., Kim, J., Hong, E., Lee, J., Cho, H. J., ... & Kim, S. J. (2022). ESRP1-regulated isoform switching of LRRFIP2 determines metastasis of gastric cancer. Nature Communications, 13(1), 6274.

Driss, L. B., Houbron, C., Britto, F., Schmitt, A., Gall, M. L., Daubas, P., & Maire, P. (2021). LRRFIP2 modulates the response to hypoxia during embryonic cardiogenesis. bioRxiv, 2021-12.

LeBlanc, R. E., Lefferts, J. A., Baker, M. L., & Linos, K. D. (2020). Novel LRRFIP2‐RAF1 fusion identified in an acral melanoma: A review of the literature on melanocytic proliferations with RAF1 fusions and the potential therapeutic implications. Journal of Cutaneous Pathology, 47(12), 1181-1186.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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