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Mouse Anti-LSAMP Recombinant Antibody (MM0445-3H44) (CBMAB-L2181-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Limbic System Associated Membrane Protein (LSAMP). The antibody can be used for immunoassay techniques, such as WB, Neut.
See all LSAMP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
MM0445-3H44
Antibody Isotype
IgG1
Application
WB, Neut

Basic Information

Immunogen
aa 29-315.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 29-315

Target

Full Name
LSAMP
Introduction
LSAMP is a member of the immunoglobulin LAMP, OBCAM and neurotrimin (IgLON) family of proteins. The encoded preproprotein is proteolytically processed to generate a neuronal surface glycoprotein. LSAMP may act as a selective homophilic adhesion molecule during axon guidance and neuronal growth in the developing limbic system. LSAMP may also function as a tumor suppressor and may play a role in neuropsychiatric disorders. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
Entrez Gene ID
4045
UniProt ID
Q13449
Alternative Names
LAMP; IGLON3; limbic system-associated membrane protein; IgLON family member 3
Function
Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hippocampal mossy fiber projection (By similarity).
Biological Process
Cell adhesionIEA:UniProtKB-KW
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane

Xu, X., Gong, C., Wang, Y., Yin, Z., Wang, X., Hu, Y., & Fang, Z. (2023). Bioinformatics analysis and experimental validation identified HMGA2/microRNA-200c-3p/LSAMP/Wnt axis as an immunological factor of patients with colorectal cancer. American Journal of Cancer Research, 13(9), 3898.

Martinez-Monleon, A., Gaarder, J., Djos, A., Kogner, P., & Fransson, S. (2023). Identification of recurrent 3q13. 31 chromosomal rearrangement indicates LSAMP as a tumor suppressor gene in neuroblastoma. International Journal of Oncology, 62(2), 1-11.

Gong, W., Li, Y., Xian, J., Yang, L., Wang, Y., Zhang, X., ... & Qiu, F. (2022). Long non-coding RNA LSAMP-1 is down-regulated in non-small cell lung cancer and predicts a poor prognosis. Cancer Cell International, 22(1), 1-16.

Morgan, D. L., Callais, V. E., Acevedo, M., & Davis, K. B. (2021, August). A potential canary in the coal mine: A critical policy analysis of the Illinois LSAMP during the COVID-19 pandemic. In Frontiers in Education (Vol. 6, p. 668394). Frontiers Media SA.

Preuss, M., Merriweather, S., Avila, J., Butler-Purry, K., Watson, K., Walton, S., ... & Texas A&M University System Louis Stokes Alliance for Minority Participation. (2021, July). The Impacts of Global Research and International Educational Experiences on Texas A&M University System LSAMP Participants. In Frontiers in Education (Vol. 6, p. 674772). Frontiers Media SA.

Chang, C. Y., Wu, K. L., Chang, Y. Y., Liu, Y. W., Huang, Y. C., Jian, S. F., ... & Hsu, Y. L. (2021). The downregulation of LSAMP expression promotes lung cancer progression and is associated with poor survival prognosis. Journal of Personalized Medicine, 11(6), 578.

San Miguel, C., & Gates, A. E. (2021, November). Synergistic Interaction of LSAMP Alliances to Improve the Graduation and Transfer of Community College Students in New Jersey United States. In Frontiers in Education (Vol. 6, p. 679865). Frontiers.

Bregin, A., Kaare, M., Jagomäe, T., Karis, K., Singh, K., Laugus, K., ... & Vasar, E. (2020). Expression and impact of Lsamp neural adhesion molecule in the serotonergic neurotransmission system. Pharmacology Biochemistry and Behavior, 198, 173017.

Hua, X., Liu, Z., Zhou, M., Tian, Y., Zhao, P. P., Pan, W. H., ... & Yu, L. N. (2019). RETRACTED: LSAMP-AS1 binds to microRNA-183–5p to suppress the progression of prostate cancer by up-regulating the tumor suppressor DCN.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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