Mouse Anti-LSM1 Recombinant Antibody (CBYJL-2061) (CBMAB-L2192-YJ)

Name: Mouse Anti-LSM1 Recombinant Antibody (CBYJL-2061)
SKU: CBMAB-L2192-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJL-2061

Application

FC, IF, IHC, WB

Immunogen

LSM1 antibody was raised in mouse using a full length recombinant protein of human LSM1 (NP_055277) produced in HEK293T cells, as the immunogen.

Specificity

Human, Dog

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)

Introduction

LSM1 is a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may function in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.

Entrez Gene ID

Human	27257
Dog	475587

UniProt ID

Human	O15116
Dog	E2R7S6

Alternative Names

CASM; YJL124C; U6 snRNA-associated Sm-like protein LSm1; LSM1 homolog, U6 small nuclear RNA associated; LSM1 mRNA degradation associated; LSM1, U6 small nuclear RNA associated; LSM1-like protein U6 small nuclear RNA associated; cancer-associated Sm protein; cancer-associated Sm-like protein; small nuclear ribonuclear CaSm

Function

Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (PubMed:18172165).
Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity).

Biological Process

Deadenylation-dependent decapping of nuclear-transcribed mRNAManual Assertion Based On ExperimentIBA:GO_Central
Histone mRNA catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
mRNA processingManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of neuron differentiationIEA:Ensembl
RNA metabolic processManual Assertion Based On ExperimentIBA:GO_Central
RNA splicingManual Assertion Based On ExperimentTAS:ProtInc
RNA splicing, via transesterification reactionsManual Assertion Based On ExperimentTAS:UniProtKB
Stem cell population maintenanceIEA:Ensembl

Cellular Location

Cytoplasm
Cytoplasm, P-body

Montemayor, E. J., Virta, J. M., Hayes, S. M., Nomura, Y., Brow, D. A., & Butcher, S. E. (2020). Molecular basis for the distinct cellular functions of the Lsm1–7 and Lsm2–8 complexes. Rna, 26(10), 1400-1413.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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