Mouse Anti-LY6G6D Recombinant Antibody (
2D6) (V2LY-0725-LY811)

Name: Mouse Anti-LY6G6D Recombinant Antibody (2D6)
SKU: V2LY-0725-LY811
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-LY6G6D Recombinant Antibody (2D6) (V2LY-0725-LY811) in ELISA

The Binding Activity of Rat Ly6g6d with Anti-LY6G6D Recombinant AntibodyActivity: Measured by its binding ability in a functional ELISA. Immobilized Rat Ly6g6d at 5 μg/mL can bind Anti-LY6G6D recombinant antibody. The EC50 is 4.245-5.843 μg/mL.

Mouse Anti-LY6G6D Recombinant Antibody (2D6) (V2LY-0725-LY811) in ELISA

The Binding Activity of Human LY6G6D with Anti-LY6G6D Recombinant AntibodyActivity: Measured by its binding ability in a functional ELISA. Immobilized Human LY6G6D at 2 μg/mL can bind Anti-LY6G6D recombinant antibody. The EC50 is 1.840-2.204 ng/mL.

Mouse Anti-LY6G6D Recombinant Antibody (2D6) (V2LY-0725-LY811) in ELISA

The Binding Activity of Mouse Ly6g6d with Anti-LY6G6D Recombinant AntibodyActivity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Ly6g6d at 2 μg/mL can bind Anti-LY6G6D recombinant antibody. The EC50 is 1.159-2.305 μg/mL.

Mouse Anti-LY6G6D Recombinant Antibody (2D6) (V2LY-0725-LY811) in ELISA

The Binding Activity of Macaca fascicularis LY6G6D with Anti-LY6G6D Recombinant AntibodyActivity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis LY6G6D at 2 μg/mL can bind Anti-LY6G6D recombinant antibody. The EC50 is 16.16-25.29 ng/mL.

Mouse Anti-LY6G6D Recombinant Antibody (2D6) (V2LY-0725-LY811) in FC

Untransfected HEK293T cells (green line) and transfected Human LY6G6D HEK293T stable cells (red line) were stained with anti-LY6G6D antibody (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Mouse IgG Fc antibody and analyzed with flow cytometry.

Mouse Anti-LY6G6D Recombinant Antibody (2D6) (V2LY-0725-LY811) in FC

Untransfected CT26 cells surface (green line) and transfected Human LY6G6D CT26 stable cells surface (red line) were stained with anti-LY6G6D antibody (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Mouse IgG Fc antibody and analyzed with flow cytometry.

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2D6

Application

ELISA, FC

Immunogen

Recombinant Human LY6G6D protein.

Host Species

Mouse

Specificity

Human, Mouse, Rat, Monkey

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
FC	1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, Glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

lymphocyte antigen 6 complex, locus G6D

Entrez Gene ID

58530

UniProt ID

O95868

Biological Process

Acetylcholine receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane
Cell projection, filopodium

PTM

O-glycosylated.

Corrales, L., Hipp, S., Martin, K., Sabarth, N., Tirapu, I., Fuchs, K., ... & Adam, P. J. (2022). LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager. Frontiers in Immunology, 13, 1008764.

Wang, P., Sun, L. L., Clark, R., Hristopoulos, M., Chiu, C. P., Dillon, M., ... & Polson, A. G. (2022). Novel Anti-LY6G6D/CD3 T-Cell–Dependent Bispecific Antibody for the Treatment of Colorectal Cancer. Molecular Cancer Therapeutics, 21(6), 974-985.

Caruso, F. P., D'andrea, M. R., Coppola, L., Landriscina, M., Condelli, V., Cerulo, L., ... & Pancione, M. (2021). LY6G6D is Epigenetically Activated in Classical Colorectal Adenocarcinoma and Hyper-Methylated in Mucinous Subtypes Determining Resistance to FOLFOX Therapeutic Regimens.

Giordano, G., Parcesepe, P., D’Andrea, M. R., Coppola, L., Di Raimo, T., Remo, A., ... & Pancione, M. (2019). JAK/Stat5-mediated subtype-specific lymphocyte antigen 6 complex, locus G6D (LY6G6D) expression drives mismatch repair proficient colorectal cancer. Journal of Experimental & Clinical Cancer Research, 38(1), 1-11.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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