Human Anti-LY6G6D Recombinant Antibody (
8I8) (V2LY-0725-LY810)

Name: Human Anti-LY6G6D Recombinant Antibody (8I8)
SKU: V2LY-0725-LY810
Rating: 5 (1 reviews)

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Tested Data

Human Anti-LY6G6D Recombinant Antibody (8I8) (V2LY-0725-LY810) in ELISA

The Binding Activity of LY6G6D with anti-LY6G6D antibodyActivity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis LY6G6D at 2 μg/mL can bind Anti-LY6G6D recombinant antibody, the EC50 is 3.963-7.154 ng/mL.

Human Anti-LY6G6D Recombinant Antibody (8I8) (V2LY-0725-LY810) in ELISA

The Binding Activity of LY6G6D with anti-LY6G6D antibodyActivity: Measured by its binding ability in a functional ELISA. Immobilized Human LY6G6D at 2 μg/mL can bind Anti-LY6G6D recombinant antibody, the EC50 is 2.816-3.741 ng/mL.

Human Anti-LY6G6D Recombinant Antibody (8I8) (V2LY-0725-LY810) in FC

Untransfected HEK293T cells surface (green line) and transfected Human LY6G6D HEK293T stable cells surface(red line) were stained with anti-LY6G6D antibody (V2LY-0725-LY810) (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Human

Clone

8I8

Application

ELISA, FC

Immunogen

Recombinant Human LY6G6D protein.

Host Species

Human

Specificity

Human, Monkey

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, Glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

lymphocyte antigen 6 complex, locus G6D

Entrez Gene ID

58530

UniProt ID

O95868

Biological Process

Acetylcholine receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane
Cell projection, filopodium

PTM

O-glycosylated.

Corrales, L., Hipp, S., Martin, K., Sabarth, N., Tirapu, I., Fuchs, K., ... & Adam, P. J. (2022). LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager. Frontiers in Immunology, 13, 1008764.

Wang, P., Sun, L. L., Clark, R., Hristopoulos, M., Chiu, C. P., Dillon, M., ... & Polson, A. G. (2022). Novel Anti-LY6G6D/CD3 T-Cell–Dependent Bispecific Antibody for the Treatment of Colorectal Cancer. Molecular Cancer Therapeutics, 21(6), 974-985.

Caruso, F. P., D'andrea, M. R., Coppola, L., Landriscina, M., Condelli, V., Cerulo, L., ... & Pancione, M. (2021). LY6G6D is Epigenetically Activated in Classical Colorectal Adenocarcinoma and Hyper-Methylated in Mucinous Subtypes Determining Resistance to FOLFOX Therapeutic Regimens.

Giordano, G., Parcesepe, P., D’Andrea, M. R., Coppola, L., Di Raimo, T., Remo, A., ... & Pancione, M. (2019). JAK/Stat5-mediated subtype-specific lymphocyte antigen 6 complex, locus G6D (LY6G6D) expression drives mismatch repair proficient colorectal cancer. Journal of Experimental & Clinical Cancer Research, 38(1), 1-11.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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