Rat Anti-LY6G6D Recombinant Antibody (CBXS-1684) (CBMAB-S0096-CQ)

This product is a rat antibody that recognizes LY6G6D. The antibody CBXS-1684 can be used for immunoassay techniques such as: WB, FC, IHC.
See all LY6G6D antibodies

Summary

Host Animal

Rat

Specificity

Mouse

Clone

CBXS-1684

Antibody Isotype

IgG2a

Application

WB, FC, IHC

Basic Information

Immunogen

NS0-derived recombinant mouse Sca-1 C-terminally truncated Ly-6E allele, Leu27-Gly119, Accession # CAA28351

Specificity

Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

lymphocyte antigen 6 complex, locus G6D

Entrez Gene ID

114654

UniProt ID

Q9Z1Q3

Alternative Names

A930024F17Rik; G6d; G6f; MEGT1; NG25; NG32; g6f-ly6g6d

Biological Process

Acetylcholine receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane
Cell projection, filopodium

PTM

O-glycosylated.

References

Corrales, L., Hipp, S., Martin, K., Sabarth, N., Tirapu, I., Fuchs, K., ... & Adam, P. J. (2022). LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager. Frontiers in Immunology, 13, 1008764.

Wang, P., Sun, L. L., Clark, R., Hristopoulos, M., Chiu, C. P., Dillon, M., ... & Polson, A. G. (2022). Novel Anti-LY6G6D/CD3 T-Cell–Dependent Bispecific Antibody for the Treatment of Colorectal Cancer. Molecular Cancer Therapeutics, 21(6), 974-985.

Caruso, F. P., D'andrea, M. R., Coppola, L., Landriscina, M., Condelli, V., Cerulo, L., ... & Pancione, M. (2021). LY6G6D is Epigenetically Activated in Classical Colorectal Adenocarcinoma and Hyper-Methylated in Mucinous Subtypes Determining Resistance to FOLFOX Therapeutic Regimens.

Giordano, G., Parcesepe, P., D’Andrea, M. R., Coppola, L., Di Raimo, T., Remo, A., ... & Pancione, M. (2019). JAK/Stat5-mediated subtype-specific lymphocyte antigen 6 complex, locus G6D (LY6G6D) expression drives mismatch repair proficient colorectal cancer. Journal of Experimental & Clinical Cancer Research, 38(1), 1-11.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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