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  • Rat Anti-LY6G6D Recombinant Antibody (CBXS-1684)

Rat Anti-LY6G6D Recombinant Antibody (CBXS-1684) (CBMAB-S0096-CQ)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rat
Clone
CBXS-1684
Application
WB, FC, IHC
Immunogen
NS0-derived recombinant mouse Sca-1 C-terminally truncated Ly-6E allele, Leu27-Gly119, Accession # CAA28351
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
lymphocyte antigen 6 complex, locus G6D
Entrez Gene ID
114654
UniProt ID
Q9Z1Q3
Alternative Names
A930024F17Rik; G6d; G6f; MEGT1; NG25; NG32; g6f-ly6g6d
Biological Process
Acetylcholine receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Cell projection, filopodium
PTM
O-glycosylated.

Corrales, L., Hipp, S., Martin, K., Sabarth, N., Tirapu, I., Fuchs, K., ... & Adam, P. J. (2022). LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager. Frontiers in Immunology, 13, 1008764.

Wang, P., Sun, L. L., Clark, R., Hristopoulos, M., Chiu, C. P., Dillon, M., ... & Polson, A. G. (2022). Novel Anti-LY6G6D/CD3 T-Cell–Dependent Bispecific Antibody for the Treatment of Colorectal Cancer. Molecular Cancer Therapeutics, 21(6), 974-985.

Caruso, F. P., D'andrea, M. R., Coppola, L., Landriscina, M., Condelli, V., Cerulo, L., ... & Pancione, M. (2021). LY6G6D is Epigenetically Activated in Classical Colorectal Adenocarcinoma and Hyper-Methylated in Mucinous Subtypes Determining Resistance to FOLFOX Therapeutic Regimens.

Giordano, G., Parcesepe, P., D’Andrea, M. R., Coppola, L., Di Raimo, T., Remo, A., ... & Pancione, M. (2019). JAK/Stat5-mediated subtype-specific lymphocyte antigen 6 complex, locus G6D (LY6G6D) expression drives mismatch repair proficient colorectal cancer. Journal of Experimental & Clinical Cancer Research, 38(1), 1-11.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-LY6G6D Recombinant Antibody (CBT4807) (CAT#: V2LY-0625-LY1608)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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