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Rat Anti-LY75 Recombinant Antibody (NLDC-145) (CBMAB-D2122-YC)

Provided herein is a Rat monoclonal antibody, which binds to Lymphocyte antigen 75 (LY75). The antibody can be used for immunoassay techniques, such as FC, IHC-Fr, ICC, IF.
See all LY75 antibodies
Published Data
Fig.1 Thymic cryosections from B6 WT, Tcra−/− Traf3fl/fl, and Tcra−/− Traf3fl/fl Foxn1-Cre+ mice were stained with a combination of anti-keratin 14 (green) and anti-DEC205 (red).
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Fig.2 Representative histograms (left panel) and total number (right panel) of CD205+ and CD205−CD80− TEC/lobe from day 7 FTOCs.
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Summary

Host Animal
Rat
Specificity
Mouse
Clone
NLDC-145
Antibody Isotype
IgG2a
Application
FC, IHC-Fr, ICC, IF

Basic Information

Immunogen
Dec205/CD205 (NLDC145) was used as immunogen
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
lymphocyte antigen 75
Introduction
LY75 has broad expression in lymph node (RPKM 17.2), appendix (RPKM 13.2) and 17 other tissues.
Entrez Gene ID
17076
UniProt ID
Q60767
Alternative Names
CD205; LY-75; CLEC13B; DEC-205; GP200-MR6
Function
Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity).
Causes reduced proliferation of B-lymphocytes.
Biological Process
EndocytosisIEA:UniProtKB-KW
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Topology
Extracellular: 28-1666
Helical: 1667-1691
Cytoplasmic: 1692-1722
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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