Mouse Anti-LY75 Recombinant Antibody (3G4) (CBMAB-L2446-YJ)

Name: Mouse Anti-LY75 Recombinant Antibody (3G4)
SKU: CBMAB-L2446-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3G4

Application

ELISA

Immunogen

LY75 aa 37-135 partial recombinant protein with GST tag. MW of the GST tag alone is 26 kDa.Immunogen type: GST fusion protein.

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 37-135

More Infomation

Target

Full Name

lymphocyte antigen 75

Introduction

Diseases associated with LY75 include Pneumonic Plague and Lipid Pneumonia. Among its related pathways are Dendritic Cells Developmental Lineage Pathway. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is LY75-CD302.

Entrez Gene ID

4065

UniProt ID

O60449

Alternative Names

CD205; LY-75; CLEC13B; DEC-205; GP200-MR6

Function

Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity).
Causes reduced proliferation of B-lymphocytes.

Biological Process

EndocytosisIEA:UniProtKB-KW
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Membrane

Topology

Extracellular: 28-1666
Helical: 1667-1691
Cytoplasmic: 1692-1722

PTM

N-glycosylated.

Wang, S. S., Zhai, G. Q., Huang, Z. G., Luo, J. Y., He, J., Huang, J. Z., ... & Chen, G. (2023). Nitidine chloride regulates cell function of bladder cancer in vitro through downregulating L ymphocyte antigen 75. Naunyn-Schmiedeberg's Archives of Pharmacology, 1-15.

Gil, M., & Kim, K. E. (2020). Systematic multiomic analysis of Ly75 gene expression and its prognostic value through the infiltration of natural killer (NK) cells in skin cutaneous melanoma. Journal of Clinical Medicine, 9(5), 1383.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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