Rat Anti-Ly86 Recombinant Antibody (CBYJL-2482) (CBMAB-L2865-YJ)

Name: Rat Anti-Ly86 Recombinant Antibody (CBYJL-2482)
SKU: CBMAB-L2865-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBYJL-2482

Application

Immunogen

Mouse RP105/MD-1 transfected NRK cells.

Specificity

Mouse

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

lymphocyte antigen 86

Introduction

Ly86 may cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Ly86 is important for efficient CD180 cell surface expression.

Entrez Gene ID

17084

UniProt ID

O88188

Alternative Names

MD1; MD-1; ly86_tv2; lymphocyte antigen 86; ly-86; protein MD-1

Function

May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity).

Biological Process

Inflammatory responseIEA:UniProtKB-KW
Innate immune responseManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentIGI:MGI

Cellular Location

Secreted, extracellular space
Associated with CD180 at the cell surface.

Zhao, M., Liu, A., Mo, L., Wan, G., Lu, F., Chen, L., ... & Deng, H. (2023). Higher expression of PLEK and LY86 as the potential biomarker of carotid atherosclerosis. Medicine, 102(42), e34445.

Salviano‐Silva, A., Farias, T. D. J., Bumiller‐Bini, V., Castro, M. D. S., Lobo‐Alves, S. C., Busch, H., ... & Malheiros, D. (2021). Genetic variability of immune‐related lncRNAs: polymorphisms in LINC‐PINT and LY86‐AS1 are associated with pemphigus foliaceus susceptibility. Experimental Dermatology, 30(6), 831-840.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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