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Rat Anti-Ly86 Recombinant Antibody (CBYJL-2483) (CBMAB-L2866-YJ)

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Basic Information

Host Animal
Rat
Clone
CBYJL-2483
Application
WB
Immunogen
aa 20-162.
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 20-162
More Infomation

Target

Full Name
lymphocyte antigen 86
Introduction
Ly86 may cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Ly86 is important for efficient CD180 cell surface expression.
Entrez Gene ID
17084
UniProt ID
O88188
Alternative Names
MD1; MD-1; ly86_tv2; lymphocyte antigen 86; ly-86; protein MD-1
Function
May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity).
Biological Process
Inflammatory responseIEA:UniProtKB-KW
Innate immune responseManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentIGI:MGI
Cellular Location
Secreted, extracellular space
Associated with CD180 at the cell surface.

Zhao, M., Liu, A., Mo, L., Wan, G., Lu, F., Chen, L., ... & Deng, H. (2023). Higher expression of PLEK and LY86 as the potential biomarker of carotid atherosclerosis. Medicine, 102(42), e34445.

Salviano‐Silva, A., Farias, T. D. J., Bumiller‐Bini, V., Castro, M. D. S., Lobo‐Alves, S. C., Busch, H., ... & Malheiros, D. (2021). Genetic variability of immune‐related lncRNAs: polymorphisms in LINC‐PINT and LY86‐AS1 are associated with pemphigus foliaceus susceptibility. Experimental Dermatology, 30(6), 831-840.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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