Sign in or Register
  • Home
  • LYPLA1
  • Rabbit Anti-LYPLA1 Recombinant Antibody (CBYJL-2248)

Rabbit Anti-LYPLA1 Recombinant Antibody (CBYJL-2248) (CBMAB-L2506-YJ)

See all LYPLA1 antibodies
Go to compare Compare Online Inquiry
Datasheet
SDS
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rabbit
Clone
CBYJL-2248
Application
ICC, IHC, IP, WB
Immunogen
Synthetic peptide corresponding to human LYPLA1.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
50 mM Tris-glycine, 0.15 M NaCl, pH 7.4, 0.05% BSA
Preservative
0.01% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
lysophospholipase I
Introduction
LYPLA1 is a member of the alpha/beta hydrolase superfamily. LYPLA1 functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7.
Entrez Gene ID
Human10434
Mouse18777
Rat25514
UniProt ID
HumanO75608
MouseP97823
RatP70470
Alternative Names
APT1; LPL1; APT-1; LPL-I; hAPT1; acyl-protein thioesterase 1; lysoPLA I; lysophospholipid-specific lysophospholipase; EC 3.1.1.5
Function
Acts as a acyl-protein thioesterase (PubMed:19439193, PubMed:20418879).
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (PubMed:20418879).
Has depalmitoylating activity toward KCNMA1 (PubMed:22399288).
Could also depalmitoylate ADRB2 (PubMed:27481942).
Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC) (PubMed:19439193).
Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (By similarity).
Has much higher thioesterase activity than lysophospholipase activity (PubMed:19439193).
Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (PubMed:21393252).By Similarity5 Publications
Biological Process
Fatty acid metabolic processIEA:UniProtKB-KW
Negative regulation of Golgi to plasma membrane protein transportIEA:Ensembl
Protein depalmitoylationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Cell membrane
Nucleus membrane
Endoplasmic reticulum
Shows predominantly a cytoplasmic localization with a weak expression in the cell membrane, nuclear membrane and endoplasmic reticulum.

Zhang, X., Liu, X., Qin, L., Tang, C., Huo, Y., Wei, J., ... & Wang, B. (2023). Averrhoa carambola extractive inhibits breast cancer via regulating CEPT1 and LYPLA1. Chinese Chemical Letters, 34(3), 107618.

Zhang, Y., Zheng, M., Zhang, L., Yuan, P., Zhou, J., Wang, Y., & Wang, H. (2022). LncRNA LOXL1-AS1 facilitates the oncogenic character in cervical cancer by the miR-526b-5p/LYPLA1 Axis. Biochemical Genetics, 60(4), 1298-1312.

Qu, M., Zhao, Y., Qing, X., Zhang, X., & Li, H. (2021). Androgen‐dependent miR‐125a‐5p targets LYPLA1 and regulates global protein palmitoylation level in late‐onset hypogonadism males. Journal of Cellular Physiology, 236(6), 4738-4749.

Mohammed, A., Zhang, C., Zhang, S., Shen, Q., Li, J., Tang, Z., & Liu, H. (2019). Inhibition of cell proliferation and migration in non‑small cell lung cancer cells through the suppression of LYPLA1. Oncology reports, 41(2), 973-980.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-LYPLA1 Recombinant Antibody (CBYJL-2248)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-LYPLA1 Recombinant Antibody (3D5) (CAT#: CBMAB-L2507-YJ)

Mouse Anti-LYPLA1 Recombinant Antibody (CBYCL-596) (CAT#: CBMAB-L0497-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry
Request bulk or custom quote Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry