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Mouse Anti-MACC1 Recombinant Antibody (CBFYM-1247) (CBMAB-M1406-FY)

This product is mouse antibody that recognizes MACC1. The antibody CBFYM-1247 can be used for immunoassay techniques such as: IHC.
See all MACC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-1247
Antibody Isotype
IgG1
Application
IHC

Basic Information

Immunogen
Recombinant protein corresponding to Human MACC1
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 40% glycerol
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MACC1, MET Transcriptional Regulator
Introduction
MACC1 is a key regulator of the hepatocyte growth factor -HGF receptor pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival.
Entrez Gene ID
346389
UniProt ID
Q6ZN28
Alternative Names
MACC1, MET Transcriptional Regulator; Metastasis Associated In Colon Cancer 1; SH3 Domain-Containing Protein 7a5; Metastasis-Associated In Colon Cancer Protein 1; Putative Binding Protein 7a5; SH3BP4L; 7A5
Function
Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.
Biological Process
Positive regulation of cell divisionIEA:UniProtKB-KW
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Cellular Location
Cytoplasm
Nucleus
Mainly found in the cytoplasm in non-metastasizing tumors.

Hohmann, T., Hohmann, U., & Dehghani, F. (2023). MACC1-induced migration in tumors: Current state and perspective. Frontiers in Oncology, 13, 1165676.

Lv, M., Jiao, Y., Yang, B., Ye, M., Di, W., Su, W., & Zhong, J. (2023). MACC1 as a Potential Target for the Treatment and Prevention of Breast Cancer. Biology, 12(3), 455.

Basti, A., Malhan, D., Dumbani, M., Dahlmann, M., Stein, U., & Relógio, A. (2022). Core-clock genes regulate proliferation and invasion via a reciprocal interplay with MACC1 in colorectal cancer cells. Cancers, 14(14), 3458.

Bähr, I., Jaeschke, L., Nimptsch, K., Janke, J., Herrmann, P., Kobelt, D., ... & Stein, U. (2022). Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association. International Journal of Oncology, 60(2), 1-11.

Zhang, X., Luo, Y., Cen, Y., Qiu, X., Li, J., Jie, M., ... & Qin, S. (2022). MACC1 promotes pancreatic cancer metastasis by interacting with the EMT regulator SNAI1. Cell Death & Disease, 13(11), 923.

Vuaroqueaux, V., Musch, A., Kobelt, D., Risch, T., Herrmann, P., Burock, S., ... & Stein, U. (2022). Elevated MACC1 expression in colorectal cancer is driven by chromosomal instability and is associated with molecular subtype and worse patient survival. Cancers, 14(7), 1749.

Treese, C., Werchan, J., von Winterfeld, M., Berg, E., Hummel, M., Timm, L., ... & Stein, U. (2022). Inhibition of MACC1-induced metastasis in esophageal and gastric adenocarcinomas. Cancers, 14(7), 1773.

Kobelt, D., Zhang, C., Clayton-Lucey, I. A., Glauben, R., Voss, C., Siegmund, B., & Stein, U. (2020). Pro-inflammatory TNF-α and IFN-γ promote tumor growth and metastasis via induction of MACC1. Frontiers in immunology, 11, 980.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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