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Rabbit Anti-MACC1 Recombinant Antibody (D2K7V) (CBMAB-CP1427-LY)

The product is antibody recognizes MACC1. The antibody D2K7V immunoassay techniques such as: WB.
See all MACC1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D2K7V
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro442 of human MACC1 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MACC1, MET Transcriptional Regulator
Introduction
MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009]
Entrez Gene ID
346389
UniProt ID
Q6ZN28
Alternative Names
MACC1; MET Transcriptional Regulator; Metastasis Associated In Colon Cancer 1; SH3 Domain-Containing Protein 7a5; Metastasis-Associated In Colon Cancer Protein 1; Putative Binding Protein 7a5; SH3BP4L; 7A5;
Function
Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.
Biological Process
Positive regulation of cell divisionIEA:UniProtKB-KW
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Cellular Location
Cytoplasm
Nucleus
Mainly found in the cytoplasm in non-metastasizing tumors.

Hohmann, T., Hohmann, U., & Dehghani, F. (2023). MACC1-induced migration in tumors: Current state and perspective. Frontiers in Oncology, 13, 1165676.

Lv, M., Jiao, Y., Yang, B., Ye, M., Di, W., Su, W., & Zhong, J. (2023). MACC1 as a Potential Target for the Treatment and Prevention of Breast Cancer. Biology, 12(3), 455.

Basti, A., Malhan, D., Dumbani, M., Dahlmann, M., Stein, U., & Relógio, A. (2022). Core-clock genes regulate proliferation and invasion via a reciprocal interplay with MACC1 in colorectal cancer cells. Cancers, 14(14), 3458.

Bähr, I., Jaeschke, L., Nimptsch, K., Janke, J., Herrmann, P., Kobelt, D., ... & Stein, U. (2022). Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association. International Journal of Oncology, 60(2), 1-11.

Zhang, X., Luo, Y., Cen, Y., Qiu, X., Li, J., Jie, M., ... & Qin, S. (2022). MACC1 promotes pancreatic cancer metastasis by interacting with the EMT regulator SNAI1. Cell Death & Disease, 13(11), 923.

Vuaroqueaux, V., Musch, A., Kobelt, D., Risch, T., Herrmann, P., Burock, S., ... & Stein, U. (2022). Elevated MACC1 expression in colorectal cancer is driven by chromosomal instability and is associated with molecular subtype and worse patient survival. Cancers, 14(7), 1749.

Treese, C., Werchan, J., von Winterfeld, M., Berg, E., Hummel, M., Timm, L., ... & Stein, U. (2022). Inhibition of MACC1-induced metastasis in esophageal and gastric adenocarcinomas. Cancers, 14(7), 1773.

Kobelt, D., Zhang, C., Clayton-Lucey, I. A., Glauben, R., Voss, C., Siegmund, B., & Stein, U. (2020). Pro-inflammatory TNF-α and IFN-γ promote tumor growth and metastasis via induction of MACC1. Frontiers in immunology, 11, 980.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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