Human MACC1 ELISA Kit (V2LY-0626-LY3966)

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Tested Data
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Basic Information

Sensitivity
0.021 ng/mL
Detection Range
0.05-10 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
96.6 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
MACC1, MET Transcriptional Regulator
Function
Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.
Biological Process
Positive regulation of cell divisionIEA:UniProtKB-KW
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Cellular Location
Cytoplasm
Nucleus
Mainly found in the cytoplasm in non-metastasizing tumors.

Hohmann, T., Hohmann, U., & Dehghani, F. (2023). MACC1-induced migration in tumors: Current state and perspective. Frontiers in Oncology, 13, 1165676.

Lv, M., Jiao, Y., Yang, B., Ye, M., Di, W., Su, W., & Zhong, J. (2023). MACC1 as a Potential Target for the Treatment and Prevention of Breast Cancer. Biology, 12(3), 455.

Basti, A., Malhan, D., Dumbani, M., Dahlmann, M., Stein, U., & Relógio, A. (2022). Core-clock genes regulate proliferation and invasion via a reciprocal interplay with MACC1 in colorectal cancer cells. Cancers, 14(14), 3458.

Bähr, I., Jaeschke, L., Nimptsch, K., Janke, J., Herrmann, P., Kobelt, D., ... & Stein, U. (2022). Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association. International Journal of Oncology, 60(2), 1-11.

Zhang, X., Luo, Y., Cen, Y., Qiu, X., Li, J., Jie, M., ... & Qin, S. (2022). MACC1 promotes pancreatic cancer metastasis by interacting with the EMT regulator SNAI1. Cell Death & Disease, 13(11), 923.

Vuaroqueaux, V., Musch, A., Kobelt, D., Risch, T., Herrmann, P., Burock, S., ... & Stein, U. (2022). Elevated MACC1 expression in colorectal cancer is driven by chromosomal instability and is associated with molecular subtype and worse patient survival. Cancers, 14(7), 1749.

Treese, C., Werchan, J., von Winterfeld, M., Berg, E., Hummel, M., Timm, L., ... & Stein, U. (2022). Inhibition of MACC1-induced metastasis in esophageal and gastric adenocarcinomas. Cancers, 14(7), 1773.

Kobelt, D., Zhang, C., Clayton-Lucey, I. A., Glauben, R., Voss, C., Siegmund, B., & Stein, U. (2020). Pro-inflammatory TNF-α and IFN-γ promote tumor growth and metastasis via induction of MACC1. Frontiers in immunology, 11, 980.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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