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Mouse Anti-MAFA Recombinant Antibody (2F1) (CBMAB-A5151-LY)

The product is antibody recognizes MAFA. The antibody 2F1 immunoassay techniques such as: WB, ELISA.
See all MAFA antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human
Clone
2F1
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
MAFA (NP_963883, 222 a.a. ~ 308 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MAF bZIP transcription factor A
Introduction
MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]).[supplied by OMIM
Entrez Gene ID
UniProt ID
Alternative Names
RIPE3b1; hMafA
Function
Transcription factor that activates insulin gene expression (PubMed:15993959, PubMed:12011435).
Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15993959).
Binds the insulin enhancer C1/RIPE3b element (PubMed:12011435).
Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (PubMed:23148532, PubMed:29339498).
Biological Process
Insulin secretionManual Assertion Based On ExperimentIDA:BHF-UCL
Nitric oxide mediated signal transductionManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB
Response to glucoseManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Involvement in disease
Insulinomatosis and diabetes mellitus (INSDM):
An autosomal dominant disorder characterized by the occurrence of multicentric insulinomas, hyperinsulinemic hypoglycemia, non insulin-dependent diabetes mellitus, and impaired glucose tolerance. Some patients also exhibit congenital cataract and/or congenital glaucoma.
PTM
Ubiquitinated, leading to its degradation by the proteasome.
Phosphorylated at tyrosines.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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