MAFA

MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]).[supplied by OMIM, Mar 2008]

MAF bZIP transcription factor A

Transcription factor that activates insulin gene expression (PubMed:15993959, PubMed:12011435).
Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15993959).
Binds the insulin enhancer C1/RIPE3b element (PubMed:12011435).
Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (PubMed:23148532, PubMed:29339498).

Insulin secretionManual Assertion Based On ExperimentIDA:BHF-UCL
Nitric oxide mediated signal transductionManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB
Response to glucoseManual Assertion Based On ExperimentIDA:UniProtKB

Nucleus

Insulinomatosis and diabetes mellitus (INSDM):
An autosomal dominant disorder characterized by the occurrence of multicentric insulinomas, hyperinsulinemic hypoglycemia, non insulin-dependent diabetes mellitus, and impaired glucose tolerance. Some patients also exhibit congenital cataract and/or congenital glaucoma.

Ubiquitinated, leading to its degradation by the proteasome.
Phosphorylated at tyrosines.