Rabbit Anti-MAFA Recombinant Antibody (CBR067G) (CBMAB-BT054LY)

Name: Rabbit Anti-MAFA Recombinant Antibody (CBR067G)
SKU: CBMAB-BT054LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBR067G

Application

WB, IHC, ICC, IHC-IF

Immunogen

aa 125-175

Specificity

Human, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

MAF bZIP transcription factor A

Introduction

MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]).[supplied by OMIM, Mar 2008]

Entrez Gene ID

Human	389692
Mouse	378435

UniProt ID

Human	Q8NHW3
Mouse	Q8CF90

Alternative Names

MAF BZIP Transcription Factor A; V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog A; Pancreatic Beta-Cell-Specific Transcriptional Activator; Transcription Factor RIPE3b1; V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A; Transcription Factor MafA; RIPE3b1; HMafA;

Function

Transcription factor that activates insulin gene expression (PubMed:15993959, PubMed:12011435).
Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15993959).
Binds the insulin enhancer C1/RIPE3b element (PubMed:12011435).
Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (PubMed:23148532, PubMed:29339498).

Biological Process

Insulin secretionManual Assertion Based On ExperimentIDA:BHF-UCL
Nitric oxide mediated signal transductionManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB
Response to glucoseManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus

Involvement in disease

Insulinomatosis and diabetes mellitus (INSDM):
An autosomal dominant disorder characterized by the occurrence of multicentric insulinomas, hyperinsulinemic hypoglycemia, non insulin-dependent diabetes mellitus, and impaired glucose tolerance. Some patients also exhibit congenital cataract and/or congenital glaucoma.

PTM

Ubiquitinated, leading to its degradation by the proteasome.
Phosphorylated at tyrosines.

Fujino, M., Ojima, M., & Takahashi, S. (2023). Exploring Large MAF Transcription Factors: Functions, Pathology, and Mouse Models with Point Mutations. Genes, 14(10), 1883.

Cataldo, L. R., Vishnu, N., Singh, T., Bertonnier-Brouty, L., Bsharat, S., Luan, C., ... & Artner, I. (2021). The MafA-target gene PPP1R1A regulates GLP1R-mediated amplification of glucose-stimulated insulin secretion in β-cells. Metabolism, 118, 154734.

Zhang, T., Wang, H., Wang, T., Wei, C., Jiang, H., Jiang, S., ... & Ma, L. (2019). Pax4 synergistically acts with Pdx1, Ngn3 and MafA to induce HuMSCs to differentiate into functional pancreatic β‑cells. Experimental and Therapeutic Medicine, 18(4), 2592-2598.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Rabbit Anti-MAFA Recombinant Antibody (D2Z6N) (CAT#: CBMAB-CP1429-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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