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Rabbit Anti-MAFA Recombinant Antibody (CBR067G) (CBMAB-BT054LY)

The product is antibody recognizes MAFA. The antibody CBR067G immunoassay techniques such as: WB, IHC, ICC, IHC-IF.
See all MAFA antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBR067G
Antibody Isotype
IgG
Application
WB, IHC, ICC, IHC-IF

Basic Information

Immunogen
aa 125-175
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MAF bZIP transcription factor A
Introduction
MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]).[supplied by OMIM, Mar 2008]
Entrez Gene ID
Human389692
Mouse378435
UniProt ID
HumanQ8NHW3
MouseQ8CF90
Alternative Names
MAF BZIP Transcription Factor A; V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog A; Pancreatic Beta-Cell-Specific Transcriptional Activator; Transcription Factor RIPE3b1; V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A; Transcription Factor MafA; RIPE3b1; HMafA;
Function
Transcription factor that activates insulin gene expression (PubMed:15993959, PubMed:12011435).
Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15993959).
Binds the insulin enhancer C1/RIPE3b element (PubMed:12011435).
Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (PubMed:23148532, PubMed:29339498).
Biological Process
Insulin secretionManual Assertion Based On ExperimentIDA:BHF-UCL
Nitric oxide mediated signal transductionManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB
Response to glucoseManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Involvement in disease
Insulinomatosis and diabetes mellitus (INSDM):
An autosomal dominant disorder characterized by the occurrence of multicentric insulinomas, hyperinsulinemic hypoglycemia, non insulin-dependent diabetes mellitus, and impaired glucose tolerance. Some patients also exhibit congenital cataract and/or congenital glaucoma.
PTM
Ubiquitinated, leading to its degradation by the proteasome.
Phosphorylated at tyrosines.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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