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Mouse Anti-MAN2A1 Recombinant Antibody (1G9) (CBMAB-A5184-LY)

The product is antibody recognizes MAN2A1. The antibody 1G9 immunoassay techniques such as: WB, ELISA.
See all MAN2A1 antibodies
Published Data
Fig. 1 Immunoblot detection using organelle-specific markers to illustrate enrichment of subcellular components by density gradient centrifugation.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1G9
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
MAN2A1 (NP_002363, 1045 a.a. ~ 1144 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
mannosidase, alpha, class 2A, member 1
Introduction
This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq]
Entrez Gene ID
4124
UniProt ID
Q16706
Alternative Names
GOLIM7; MANA2; MANII
Function
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
Biological Process
In utero embryonic developmentIEA:Ensembl
Liver developmentIEA:Ensembl
Lung alveolus developmentIEA:Ensembl
Mannose metabolic processIEA:InterPro
Mitochondrion organizationIEA:Ensembl
N-glycan processingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of neurogenesisIEA:Ensembl
Protein deglycosylationManual Assertion Based On ExperimentIBA:GO_Central
Protein glycosylationIEA:UniProtKB-UniPathway
Respiratory gaseous exchange by respiratory systemIEA:Ensembl
Retina morphogenesis in camera-type eyeIEA:Ensembl
Vacuole organizationIEA:Ensembl
Viral protein processingTAS:Reactome
Cellular Location
Golgi apparatus membrane
Topology
Cytoplasmic: 1-5
Helical: 6-26
Lumenal: 27-1144
PTM
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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