MAN2A1

This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq]

Full Name

mannosidase, alpha, class 2A, member 1

Function

Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.

Biological Process

In utero embryonic developmentIEA:Ensembl
Liver developmentIEA:Ensembl
Lung alveolus developmentIEA:Ensembl
Mannose metabolic processIEA:InterPro
Mitochondrion organizationIEA:Ensembl
N-glycan processingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of neurogenesisIEA:Ensembl
Protein deglycosylationManual Assertion Based On ExperimentIBA:GO_Central
Protein glycosylationIEA:UniProtKB-UniPathway
Respiratory gaseous exchange by respiratory systemIEA:Ensembl
Retina morphogenesis in camera-type eyeIEA:Ensembl
Vacuole organizationIEA:Ensembl
Viral protein processingTAS:Reactome

Cellular Location

Golgi apparatus membrane

Topology

Cytoplasmic: 1-5
Helical: 6-26
Lumenal: 27-1144

PTM

Glycosylated.