• Home
  • MAN2A1
  • Mouse Anti-MAN2A1 Recombinant Antibody (CBFYM-1364)

Mouse Anti-MAN2A1 Recombinant Antibody (CBFYM-1364) (CBMAB-M1523-FY)

See all MAN2A1 antibodies
Go to compare Compare Online Inquiry
Datasheet
SDS
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBFYM-1364
Application
IHC-P, ICC, IF
Specificity
Mouse, Rat, Hamster
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Antiserum
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
mannosidase, alpha, class 2A, member 1
Introduction
This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.
Entrez Gene ID
Hamster100757006
Mouse17158
Rat25478
UniProt ID
HamsterA0A1U7QQP6
MouseP27046
RatP28494
Alternative Names
Mannosidase Alpha Class 2A Member 1; Mannosyl-Oligosaccharide 1,3-1,6-Alpha-Mannosidase; Golgi Integral Membrane Protein 7; Golgi Alpha-Mannosidase II; EC 3.2.1.114; AMan II; MANA2; Mannosidase, Alpha, Class 2A, Member 1
Function
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
Biological Process
In utero embryonic developmentIEA:Ensembl
Liver developmentIEA:Ensembl
Lung alveolus developmentIEA:Ensembl
Mannose metabolic processIEA:InterPro
Mitochondrion organizationIEA:Ensembl
N-glycan processingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of neurogenesisIEA:Ensembl
Protein deglycosylationManual Assertion Based On ExperimentIBA:GO_Central
Protein glycosylationIEA:UniProtKB-UniPathway
Respiratory gaseous exchange by respiratory systemIEA:Ensembl
Retina morphogenesis in camera-type eyeIEA:Ensembl
Vacuole organizationIEA:Ensembl
Viral protein processingTAS:Reactome
Cellular Location
Golgi apparatus membrane
Topology
Cytoplasmic: 1-5
Helical: 6-26
Lumenal: 27-1144
PTM
Glycosylated.

Desaunay, M., Voisset, E., Letard, S., Roche, P., & De Sepulveda, P. (2023). The recurrent liver MAN2A1-FER oncoprotein lacks kinase activity: Implications for the use of tyrosine kinase inhibitors. Cellular and Molecular Gastroenterology and Hepatology.

Wang, Y., Zhao, J., Fu, G., Sheng, C., Zhu, J., Zhong, T., ... & Jiang, Z. (2022). MAN2A1 predicts prognosis and progression through cancer-related pathways in colorectal cancer. Translational Cancer Research, 11(10), 3686.

Shi, S., Gu, S., Han, T., Zhang, W., Huang, L., Li, Z., ... & Liu, X. S. (2020). Inhibition of MAN2A1 Enhances the Immune Response to Anti–PD-L1 in Human Tumors. Clinical Cancer Research, 26(22), 5990-6002.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-MAN2A1 Recombinant Antibody (CBFYM-1364)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-MAN2A1 Recombinant Antibody (1G9) (CAT#: CBMAB-A5184-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry
Request bulk or custom quote Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry