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Mouse Anti-MAN2A1 Recombinant Antibody (CBFYM-1364) (CBMAB-M1523-FY)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Hamster
Clone
CBFYM-1364
Antibody Isotype
IgG2b
Application
IHC-P, ICC, IF

Basic Information

Specificity
Mouse, Rat, Hamster
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Antiserum
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
mannosidase, alpha, class 2A, member 1
Introduction
This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.
Entrez Gene ID
Hamster100757006
Mouse17158
Rat25478
UniProt ID
HamsterA0A1U7QQP6
MouseP27046
RatP28494
Alternative Names
Mannosidase Alpha Class 2A Member 1; Mannosyl-Oligosaccharide 1,3-1,6-Alpha-Mannosidase; Golgi Integral Membrane Protein 7; Golgi Alpha-Mannosidase II; EC 3.2.1.114; AMan II; MANA2; Mannosidase, Alpha, Class 2A, Member 1
Function
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
Biological Process
In utero embryonic developmentIEA:Ensembl
Liver developmentIEA:Ensembl
Lung alveolus developmentIEA:Ensembl
Mannose metabolic processIEA:InterPro
Mitochondrion organizationIEA:Ensembl
N-glycan processingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of neurogenesisIEA:Ensembl
Protein deglycosylationManual Assertion Based On ExperimentIBA:GO_Central
Protein glycosylationIEA:UniProtKB-UniPathway
Respiratory gaseous exchange by respiratory systemIEA:Ensembl
Retina morphogenesis in camera-type eyeIEA:Ensembl
Vacuole organizationIEA:Ensembl
Viral protein processingTAS:Reactome
Cellular Location
Golgi apparatus membrane
Topology
Cytoplasmic: 1-5
Helical: 6-26
Lumenal: 27-1144
PTM
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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