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Mouse Anti-MAP3K2 Recombinant Antibody (CBFYM-1521) (CBMAB-M1684-FY)

This product is mouse antibody that recognizes MAP3K2. The antibody CBFYM-1521 can be used for immunoassay techniques such as: ICC, IF, WB.
See all MAP3K2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBFYM-1521
Antibody Isotype
IgG1
Application
ICC, IF, WB

Basic Information

Immunogen
Recombinant fragment of human MAP3K2 expressed in E. Coli
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.03% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
Introduction
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.
Entrez Gene ID
Human10746
Mouse26405
UniProt ID
HumanQ9Y2U5
MouseQ61083
Alternative Names
Mitogen-Activated Protein Kinase Kinase Kinase 2; MAPK/ERK Kinase Kinase 2; MAP/ERK Kinase Kinase 2; MEK Kinase 2; MEKK 2; MEKK2; EC 2.7.11.25; MAPKKK2; MEKK2B
Function
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity).
Plays a role in caveolae kiss-and-run dynamics.
Biological Process
Cellular response to mechanical stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Nucleus
Upon EGF stimulation, translocates into the nucleus.
PTM
Autophosphorylated.
Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation.

Ikram, S., Rege, A., Negesse, M. Y., Casanova, A. G., Reynoird, N., & Green, E. M. (2023). The SMYD3-MAP3K2 signaling axis promotes tumor aggressiveness and metastasis in prostate cancer. Science Advances, 9(46), eadi5921.

Wan, Y., Huang, J., Song, Y., Gu, C., Kong, J., Zuo, L., & Chen, J. (2022). hsa-miR-340-5p inhibits epithelial–mesenchymal transition in endometriosis by targeting MAP3K2 and inactivating MAPK/ERK signaling. Open Medicine, 17(1), 566-576.

Liu, J., Xu, S., Liu, S., & Chen, B. (2021). miR‑3613‑3p/MAP3K2/p38/caspase‑3 pathway regulates the heat‑stress‑induced apoptosis of endothelial cells. Molecular Medicine Reports, 24(3), 1-13.

Yuan, Q., Basit, A., Liang, W., Qu, R., Luan, Y., Ren, C., ... & Wu, D. (2021). Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3. Science translational medicine, 13(591), eabc2499.

Zhang, Y., Wang, D., Zhu, T., Yu, J., Wu, X., Lin, W., ... & Zhu, J. (2021). CircPUM1 promotes hepatocellular carcinoma progression through the miR‐1208/MAP3K2 axis. Journal of Cellular and Molecular Medicine, 25(1), 600-612.

Wu, N., Sun, H., Zhao, X., Zhang, Y., Tan, J., Qi, Y., ... & Su, B. (2021). MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Nature, 592(7855), 606-610.

Liao, X., Wen, L., & Luo, L. (2021). The effect and mechanism of lncRNA NR2F1-As1/miR-493-5p/MAP3K2 axis in the progression of gastric cancer. Journal of Oncology, 2021, 1-10.

Shi, X., Liu, T. T., Yu, X. N., Balakrishnan, A., Zhu, H. R., Guo, H. Y., ... & Shen, X. Z. (2020). microRNA-93-5p promotes hepatocellular carcinoma progression via a microRNA-93-5p/MAP3K2/c-Jun positive feedback circuit. Oncogene, 39(35), 5768-5781.

Liu, L., Li, Y., Zhang, R., Li, C., Xiong, J., & Wei, Y. (2020). MIR205HG acts as a ceRNA to expedite cell proliferation and progression in lung squamous cell carcinoma via targeting miR-299-3p/MAP3K2 axis. BMC Pulmonary Medicine, 20(1), 1-9.

Wang, M., Lv, G., Jiang, C., Xie, S., & Wang, G. (2019). miR-302a inhibits human HepG2 and SMMC-7721 cells proliferation and promotes apoptosis by targeting MAP3K2 and PBX3. Scientific Reports, 9(1), 2032.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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