MAP3K2

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.

MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2

Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity).
Plays a role in caveolae kiss-and-run dynamics.

Cellular response to mechanical stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentTAS:ProtInc

Cytoplasm
Nucleus
Upon EGF stimulation, translocates into the nucleus.

Autophosphorylated.
Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation.