Mouse Anti-MAP4K3 Recombinant Antibody (CBFYM-1550) (CBMAB-M1715-FY)

Name: Mouse Anti-MAP4K3 Recombinant Antibody (CBFYM-1550)
SKU: CBMAB-M1715-FY
Rating: 5 (1 reviews)

See all MAP4K3 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-1550

Application

WB, ELISA

Immunogen

This MAP4K3 monoclonal antibody is generated from mouse immunized with MAP4K3 recombinant protein

Specificity

Human

Antibody Isotype

IgM, k

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

0.09% Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3

Introduction

This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

Entrez Gene ID

8491

UniProt ID

Q8IVH8

Alternative Names

Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3; Germinal Center Kinase-Related Protein Kinase; MAPK/ERK Kinase Kinase Kinase 3; MEK Kinase Kinase 3; EC 2.7.11.1; RAB8IPL1; MEKKK 3

Function

May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

Biological Process

Intracellular signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
JNK cascadeManual Assertion Based On ExperimentTAS:ProtInc
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Response to tumor necrosis factorManual Assertion Based On ExperimentIDA:UniProtKB
Response to UVManual Assertion Based On ExperimentIDA:UniProtKB

Chuang, H. C., Hung, W. T., Chen, Y. M., Hsu, P. M., Yen, J. H., Lan, J. L., & Tan, T. H. (2022). Genomic sequencing and functional analyses identify MAP4K3/GLK germline and somatic variants associated with systemic lupus erythematosus. Annals of the Rheumatic Diseases, 81(2), 243-254.

Becker-Greene, D., Li, H., Perez-Cremades, D., Wu, W., Bestepe, F., Ozdemir, D., ... & Icli, B. (2021). MiR-409-3p targets a MAP4K3-ZEB1-PLGF signaling axis and controls brown adipose tissue angiogenesis and insulin resistance. Cellular and Molecular Life Sciences, 78, 7663-7679.

Li, J., Yan, L., Luo, J., Tong, L., Gao, Y., Feng, W., ... & Sun, Z. (2021). Baicalein suppresses growth of non-small cell lung carcinoma by targeting MAP4K3. Biomedicine & Pharmacotherapy, 133, 110965.

Shi, Y., Mo, X., Hong, S., Li, T., Chen, B., & Chen, G. (2020). Studying the role and molecular mechanisms of MAP4K3 in sorafenib resistance of hepatocellular carcinoma. BioMed Research International, 2020.

Wang, Z., Han, Z., Zhang, L., Zhang, S., & Wang, B. (2019). MicroRNA‑98‑5p regulates the proliferation and apoptosis of A549 cells by targeting MAP4K3. Oncology Letters, 18(4), 4288-4293.

Chuang, H. C., & Tan, T. H. (2019). MAP4K3/GLK in autoimmune disease, cancer and aging. Journal of Biomedical Science, 26, 1-8.

Chuang, H. C., Chang, C. C., Teng, C. F., Hsueh, C. H., Chiu, L. L., Hsu, P. M., ... & Tan, T. H. (2019). MAP4K3/GLK promotes lung cancer metastasis by phosphorylating and activating IQGAP1. Cancer Research, 79(19), 4978-4993.

Liu, F., Yin, R., Chen, X., Chen, W., Qian, Y., Zhao, Y., ... & Zhang, Y. (2019). Over-expression of miR-206 decreases the Euthyrox-resistance by targeting MAP4K3 in papillary thyroid carcinoma. Biomedicine & Pharmacotherapy, 114, 108605.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-MAP4K3 Recombinant Antibody (CBFYM-1550)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-MAP4K3 Recombinant Antibody (CBFYM-1551) (CAT#: CBMAB-M1716-FY)

Mouse Anti-MAP4K3 Recombinant Antibody (A997) (CAT#: CBMAB-AP11664LY)

Recombinant Mouse Anti-MAP4K3 Antibody (CBAb160) (CAT#: CBMAB-Ab160-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry