Human Recombinant MAP4K3, Active protein, GST Tag (V2LY-0526-LY5449)

Name: Human Recombinant MAP4K3, Active protein, GST Tag
SKU: V2LY-0526-LY5449
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant MAP4K3, Active protein, GST Tag consist of Amino Acid: 1-380 and predicts a molecular mass of 70 kDa.

Molecule Mass

70 kDa

Sequence

Amino Acid: 1-380

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3

Function

May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

Biological Process

Intracellular signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
JNK cascadeManual Assertion Based On ExperimentTAS:ProtInc
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Response to tumor necrosis factorManual Assertion Based On ExperimentIDA:UniProtKB
Response to UVManual Assertion Based On ExperimentIDA:UniProtKB

Chuang, H. C., Hung, W. T., Chen, Y. M., Hsu, P. M., Yen, J. H., Lan, J. L., & Tan, T. H. (2022). Genomic sequencing and functional analyses identify MAP4K3/GLK germline and somatic variants associated with systemic lupus erythematosus. Annals of the Rheumatic Diseases, 81(2), 243-254.

Becker-Greene, D., Li, H., Perez-Cremades, D., Wu, W., Bestepe, F., Ozdemir, D., ... & Icli, B. (2021). MiR-409-3p targets a MAP4K3-ZEB1-PLGF signaling axis and controls brown adipose tissue angiogenesis and insulin resistance. Cellular and Molecular Life Sciences, 78, 7663-7679.

Li, J., Yan, L., Luo, J., Tong, L., Gao, Y., Feng, W., ... & Sun, Z. (2021). Baicalein suppresses growth of non-small cell lung carcinoma by targeting MAP4K3. Biomedicine & Pharmacotherapy, 133, 110965.

Shi, Y., Mo, X., Hong, S., Li, T., Chen, B., & Chen, G. (2020). Studying the role and molecular mechanisms of MAP4K3 in sorafenib resistance of hepatocellular carcinoma. BioMed Research International, 2020.

Wang, Z., Han, Z., Zhang, L., Zhang, S., & Wang, B. (2019). MicroRNA‑98‑5p regulates the proliferation and apoptosis of A549 cells by targeting MAP4K3. Oncology Letters, 18(4), 4288-4293.

Chuang, H. C., & Tan, T. H. (2019). MAP4K3/GLK in autoimmune disease, cancer and aging. Journal of Biomedical Science, 26, 1-8.

Chuang, H. C., Chang, C. C., Teng, C. F., Hsueh, C. H., Chiu, L. L., Hsu, P. M., ... & Tan, T. H. (2019). MAP4K3/GLK promotes lung cancer metastasis by phosphorylating and activating IQGAP1. Cancer Research, 79(19), 4978-4993.

Liu, F., Yin, R., Chen, X., Chen, W., Qian, Y., Zhao, Y., ... & Zhang, Y. (2019). Over-expression of miR-206 decreases the Euthyrox-resistance by targeting MAP4K3 in papillary thyroid carcinoma. Biomedicine & Pharmacotherapy, 114, 108605.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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