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Mouse Anti-MAPK6 Recombinant Antibody (CBT508) (V2LY-0625-LY3464)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT508
Antibody Isotype
IgG
Application
WB, FC, ELISA

Basic Information

Immunogen
Purified recombinant fragment of human ERK 3 expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:10,000
FC1:200-1:400
WB1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Buffer
BSA, Glycerol
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Mitogen-Activated Protein Kinase 6
Entrez Gene ID
5597
UniProt ID
Q16659
Function
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).
Biological Process
Cell cycleIEA:UniProtKB-KW
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of dendritic spine developmentIEA:Ensembl
Protein phosphorylationISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Nucleus
Translocates to the cytoplasm following interaction with MAPKAPK5.
PTM
Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites.
Ubiquitination at Met-1 leads to degradation by the proteasome pathway.
More Infomation

Samari, E., Chashmi, N. A., Ghanati, F., Sajedi, R. H., Gust, A. A., Haghdoust, F., ... & Fuss, E. (2022). Interactions between second messengers, SA and MAPK6 signaling pathways lead to chitosan-induced lignan production in Linum album cell culture. Industrial Crops and Products, 177, 114525.

Zhu, H., Liu, Q., Yang, X., Ding, C., Wang, Q., & Xiong, Y. (2022). LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to promote the development of lung squamous cell carcinoma via activating MAPK signaling pathway. Cancer Gene Therapy, 29(8-9), 1285-1295.

Hou, G., Yang, J., Tang, J., & He, Y. (2021). LncRNA GAS6-AS2 promotes non-small-cell lung cancer cell proliferation via regulating miR-144-3p/MAPK6 axis. Cell Cycle, 20(2), 179-193.

Cai, Q., Zhou, W., Wang, W., Dong, B., Han, D., Shen, T., ... & Yang, F. (2021). MAPK6-AKT signaling promotes tumor growth and resistance to mTOR kinase blockade. Science advances, 7(46), eabi6439.

Zhang, M., Wang, H., Zhang, X., & Liu, F. (2021). miR‑653‑5p suppresses the growth and migration of breast cancer cells by targeting MAPK6. Molecular Medicine Reports, 23(3), 1-1.

Wang, R., & Xu, B. (2021). TGF-β1-modified MSC-derived exosomal miR-135b attenuates cartilage injury via promoting M2 synovial macrophage polarization by targeting MAPK6. Cell and tissue research, 384, 113-127.

Cai, Q., Wang, W., Dong, B., Zhou, W., Shen, T., Moore, D. D., ... & Yang, F. (2020). Oncogenic Activation of AKT by MAPK6. bioRxiv, 2020-09.

Luo, M., Sun, Q., Zhao, H., Tao, J., & Yan, D. (2020). Long noncoding RNA NEAT1 sponges miR‐495‐3p to enhance myocardial ischemia‐reperfusion injury via MAPK6 activation. Journal of Cellular Physiology, 235(1), 105-113.

Wu, F., Mo, Q., Wan, X., Dan, J., & Hu, H. (2019). NEAT1/hsa‐mir‐98‐5p/MAPK6 axis is involved in non–small‐cell lung cancer development. Journal of cellular biochemistry, 120(3), 2836-2846.

Huang, Z. Q., Xu, W., Wu, J. L., Lu, X., & Chen, X. M. (2019). MicroRNA-374a protects against myocardial ischemia-reperfusion injury in mice by targeting the MAPK6 pathway. Life sciences, 232, 116619.

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For research use only. Not intended for any clinical use.

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