MAPK6

The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]
Full Name
Mitogen-Activated Protein Kinase 6
Function
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).
Biological Process
Cell cycleIEA:UniProtKB-KW
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of dendritic spine developmentIEA:Ensembl
Protein phosphorylationISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Nucleus
Translocates to the cytoplasm following interaction with MAPKAPK5.
PTM
Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites.
Ubiquitination at Met-1 leads to degradation by the proteasome pathway.
View more

Anti-MAPK6 antibodies

+ Filters
Loading...

Mouse Anti-MAPK6 Recombinant Antibody (4E8) (CBMAB-EN1357-LY)

Go to compareCompare
Target: MAPK6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 4E8
Application*: WB, FC, ELISA.
Datasheet SDS

Mouse Anti-MAPK6 Recombinant Antibody (CBFYM-1633) (CBMAB-M1800-FY)

Go to compareCompare
Target: MAPK6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-1633
Application*: WB, E
Datasheet SDS

Mouse Anti-MAPK6 (AA 612-721) Recombinant Antibody (CBFYM-1632) (CBMAB-M1799-FY)

Go to compareCompare
Target: MAPK6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-1632
Application*: IF, WB
Datasheet SDS

Mouse Anti-MAPK6 Recombinant Antibody (CBFYM-1630) (CBMAB-M1797-FY)

Go to compareCompare
Target: MAPK6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1630
Application*: E, F, WB
Datasheet SDS

Mouse Anti-MAPK6 (AA 344-721) Recombinant Antibody (CBFYM-1629) (CBMAB-M1796-FY)

Go to compareCompare
Target: MAPK6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-1629
Application*: IH, WB
Datasheet SDS

Rabbit Anti-MAPK6 (N-terminus) Recombinant Antibody (CBFYE-1541) (CBMAB-E2182-FY)

Go to compareCompare
Target: MAPK6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYE-1541
Application*: F, IH, WB
Datasheet SDS

Mouse Anti-MAPK6 (AA 345-721) Recombinant Antibody (CBFYE-1540) (CBMAB-E2181-FY)

Go to compareCompare
Target: MAPK6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYE-1540
Application*: IF, WB
Datasheet SDS

Mouse Anti-MAPK6 (AA 345-721) Recombinant Antibody (CBFYE-1539) (CBMAB-E2180-FY)

Go to compareCompare
Target: MAPK6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYE-1539
Application*: IH, P, WB
Datasheet SDS

Mouse Anti-MAPK6 Recombinant Antibody (CBFYE-1538) (CBMAB-E2179-FY)

Go to compareCompare
Target: MAPK6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-1538
Application*: E, WB, P, IF, F
Datasheet SDS

Mouse Anti-MAPK6 Recombinant Antibody (CBT508) (V2LY-0625-LY3464)

Go to compareCompare
Target: MAPK6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT508
Application*: WB, F, E
Datasheet SDS

Mouse Anti-MAPK6 Recombinant Antibody (CBT3213) (V2LY-0625-LY2537)

Go to compareCompare
Target: MAPK6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3213
Application*: F
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
online inquiry
Online Inquiry
Happy Holidays
Happy Holidays close ad