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Rabbit Anti-MAPK6 (N-terminus) Recombinant Antibody (CBFYE-1541) (CBMAB-E2182-FY)

This product is rabbit antibody that recognizes MAPK6. The antibody CBFYE-1541 can be used for immunoassay techniques such as: FC, IHC, WB.
See all MAPK6 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBFYE-1541
Antibody Isotype
IgG
Application
FC, IHC, WB

Basic Information

Immunogen
Synthetic peptide corresponding to human ERK3 at N-terminal
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA, 40% glycerol
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
N-terminus

Target

Full Name
Mitogen-Activated Protein Kinase 6
Introduction
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.
Entrez Gene ID
Human5597
Mouse50772
Rat58840
UniProt ID
HumanQ16659
MouseQ61532
RatP27704
Alternative Names
Mitogen-Activated Protein Kinase 6; Extracellular Signal-Regulated Kinase 3; MAP Kinase Isoform P97; MAP Kinase 6; EC 2.7.11.24; P97-MAPK; MAPK 6; PRKM6; ERK-3
Function
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).
Biological Process
Cell cycleIEA:UniProtKB-KW
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of dendritic spine developmentIEA:Ensembl
Protein phosphorylationISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Nucleus
Translocates to the cytoplasm following interaction with MAPKAPK5.
PTM
Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites.
Ubiquitination at Met-1 leads to degradation by the proteasome pathway.

Samari, E., Chashmi, N. A., Ghanati, F., Sajedi, R. H., Gust, A. A., Haghdoust, F., ... & Fuss, E. (2022). Interactions between second messengers, SA and MAPK6 signaling pathways lead to chitosan-induced lignan production in Linum album cell culture. Industrial Crops and Products, 177, 114525.

Zhu, H., Liu, Q., Yang, X., Ding, C., Wang, Q., & Xiong, Y. (2022). LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to promote the development of lung squamous cell carcinoma via activating MAPK signaling pathway. Cancer Gene Therapy, 29(8-9), 1285-1295.

Hou, G., Yang, J., Tang, J., & He, Y. (2021). LncRNA GAS6-AS2 promotes non-small-cell lung cancer cell proliferation via regulating miR-144-3p/MAPK6 axis. Cell Cycle, 20(2), 179-193.

Cai, Q., Zhou, W., Wang, W., Dong, B., Han, D., Shen, T., ... & Yang, F. (2021). MAPK6-AKT signaling promotes tumor growth and resistance to mTOR kinase blockade. Science advances, 7(46), eabi6439.

Zhang, M., Wang, H., Zhang, X., & Liu, F. (2021). miR‑653‑5p suppresses the growth and migration of breast cancer cells by targeting MAPK6. Molecular Medicine Reports, 23(3), 1-1.

Wang, R., & Xu, B. (2021). TGF-β1-modified MSC-derived exosomal miR-135b attenuates cartilage injury via promoting M2 synovial macrophage polarization by targeting MAPK6. Cell and tissue research, 384, 113-127.

Cai, Q., Wang, W., Dong, B., Zhou, W., Shen, T., Moore, D. D., ... & Yang, F. (2020). Oncogenic Activation of AKT by MAPK6. bioRxiv, 2020-09.

Luo, M., Sun, Q., Zhao, H., Tao, J., & Yan, D. (2020). Long noncoding RNA NEAT1 sponges miR‐495‐3p to enhance myocardial ischemia‐reperfusion injury via MAPK6 activation. Journal of Cellular Physiology, 235(1), 105-113.

Wu, F., Mo, Q., Wan, X., Dan, J., & Hu, H. (2019). NEAT1/hsa‐mir‐98‐5p/MAPK6 axis is involved in non–small‐cell lung cancer development. Journal of cellular biochemistry, 120(3), 2836-2846.

Huang, Z. Q., Xu, W., Wu, J. L., Lu, X., & Chen, X. M. (2019). MicroRNA-374a protects against myocardial ischemia-reperfusion injury in mice by targeting the MAPK6 pathway. Life sciences, 232, 116619.

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For research use only. Not intended for any clinical use.

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